{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T06:59:01Z","timestamp":1757573941449},"reference-count":55,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2004,10,9]],"date-time":"2004-10-09T00:00:00Z","timestamp":1097280000000},"content-version":"vor","delay-in-days":6028,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Comparative Neurology"],"published-print":{"date-parts":[[1988,4,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>An antibody raised in rabbits against a GABA\u2010BSA conjugate was used together with the PAP technique to label elements in the neostriatum of three Old World monkeys. Light microscopy revealed numerous immunoreactive medium\u2010size neurons of various staining intensities, some of which had indented nuclei, as well as an occasional large cell. The neuropil showed a plexus of fine processes with frequent puncta, Ultrastructurally, the medium\u2010size GABA\u2010positive neurons were of two types: one with smooth nuclei and scanty cytoplasm, similar to spiny I cells, the other with invaginated nuclear envelopes and more abundant perikaryon, resembling the aspiny type. Correspondingly, labeled dendrites were either spiny or varicose. Some stained axons were myelinated, and the boutons had either large and ovoid, or small and pleomorphic vesicles. All of these boutons formed symmetric synapses, the former type with GABA\u2010positive dendritic shafts but also with unlabeled dendrites; the latter type usually with GABA\u2010negative elements, either dendrites, dendritic spines, or somata. Synapses were also observed between unreactive boutons and immunostained dendrites. Terminals with densely packed, small round vesicles that established asymmetric synapses with spines were always GABA\u2010negative. Glial elements were consistently unlabeled, save, for some astroglial endfeet. These findings provide positive evidence for the existence of two classes of GABAergic striatal neurons corresponding to a long\u2010axoned spiny I type and an aspiny interneuron. Furthermore, the simultaneous labeling of GABA\u2010immunoreactive presynaptic and postsynaptic profiles offers possible morphologic bases for the various kinds of intrastriatal inhibitory processes, including the feedforward, feedback, and \u201cautaptic\u201d types.<\/jats:p>","DOI":"10.1002\/cne.902700202","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T18:51:18Z","timestamp":1104605478000},"page":"157-170","source":"Crossref","is-referenced-by-count":63,"title":["GABAergic elements in the neuronal circuits of the monkey neostriatum: A light and electron microscopic immunocytochemical study"],"prefix":"10.1002","volume":"270","author":[{"given":"Pedro","family":"Pasik","sequence":"first","affiliation":[]},{"given":"Tauba","family":"Pasik","sequence":"additional","affiliation":[]},{"given":"Gay R.","family":"Holstein","sequence":"additional","affiliation":[]},{"given":"Jozsef","family":"H\u00e1mori","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2004,10,9]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/0006-8993(84)90850-3","article-title":"Localization of immunoreactive enkephalins in GABA synthesizing neurons of the rat neostriatum","volume":"300","author":"Aronin N.","year":"1984","journal-title":"Brain Res."},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(75)90339-X"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(82)90159-2"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902130202"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902370102"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01148468"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.7256286"},{"key":"e_1_2_1_9_1","first-page":"1326","article-title":"In situ hybridization of mRNAs for GAD, tyrosine hydroxylase and takinins in the basal ganglia","volume":"12","author":"Chesselet M. 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