{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T01:59:26Z","timestamp":1768787966421,"version":"3.49.0"},"reference-count":103,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2004,10,9]],"date-time":"2004-10-09T00:00:00Z","timestamp":1097280000000},"content-version":"vor","delay-in-days":5953,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Comparative Neurology"],"published-print":{"date-parts":[[1988,6,22]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The distribution of neurotensin immunoreactivity in the basal ganglia of the adult rat was evaluated by studying alternate serial vibratome sections that were exposed to antiserum against neurotensin, substance P, or cholecystokinin. It was observed that a heterogeneous distribution of neurotensin\u2010immunoreactive fibers and terminals contributes to the neurochemical compartmentation of the ventral pallidum and ventral striatum, and that significant numbers of neurotensin\u2010immunoreactive neurons occupy striatal districts of the olfactory tubercle, nucleus accumbens, and ventromedial caudate\u2010putamen. An intense band of pallidal neurotensin immunoreactivity characterizes the medial part of the ventral pallidum <jats:italic>adjacent<\/jats:italic> to the nucleus accumbens, whose medial boundary is conveniently defined in sections incubated with cholecystokinin antiserum. Electron microscopic studies showed that the pallidal plexus of neurotensin\u2010immunoreactive elements consists primarily of boutons, which contact large dendrites in arrangements that in all respects appear to be of the classical striatopallidal variety. A gradual decrese in immunolabel was observed approaching the lateral parts of the ventral pallidum, which display sparse neurotensin immunoreactivity. The results thus indicate the existence of a significant neurotensinergic striatopallidal pathway confined primarily, if not exclusively, to the medial part of the ventral striatopallidal system. The contribution of neurotensin\u2010immunoreactive fibers and terminals to the compartmentation of ventral striatum is expressed most vividly in their exclusion from clusters of tightly packed medium\u2010sized neurons, many of which are intensely substance P immunoreactive. Such clusters appear identical with those previously described as rich in opiate receptors and poor in acetylcholinesterase activity. In the ventral striatal region where the nucleus accumbens and ventromedial caudate\u2010putamen merge, neurotensin\u2010immunoreactive neurons are organized in clusters. Further rostral in the nucleus accumbens, they are more evenly distributed. Few were found in the dorsolateral quadrant of the neostriatum.<\/jats:p>","DOI":"10.1002\/cne.902720406","type":"journal-article","created":{"date-parts":[[2005,5,27]],"date-time":"2005-05-27T21:22:39Z","timestamp":1117228959000},"page":"516-535","source":"Crossref","is-referenced-by-count":181,"title":["Ventral striatopallidal parts of the basal ganglia in the rat: I. Neurochemical compartmentation as reflected by the distributions of neurotensin and substance P immunoreactivity"],"prefix":"10.1002","volume":"272","author":[{"given":"D. S.","family":"Zahm","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Heimer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,9]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1146\/annurev.ne.09.030186.002041","article-title":"Parallel organization of functionally segregated circuits linking basal ganglia and cortex","volume":"9","author":"Alexander G. E.","year":"1986","journal-title":"Annu. Rev. Neurosci."},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","unstructured":"Alheid G. F. andL.Heimer(1988) New perspectives in basal forebrain organization of special relevance for neuropsychiatric disorders; the striatopallidal amygdaloid and corticopetal components of substantia innominata.Neuroscience(in press).","DOI":"10.1016\/0306-4522(88)90217-5"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0361-9230(83)90128-4"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(84)90257-4"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901840104"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(85)90287-2"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(87)90110-2"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(79)91001-1"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902320406"},{"key":"e_1_2_1_11_1","first-page":"55","volume-title":"Handbook of Chemical Neuroanatomy","author":"Bj\u00f6rklund A.","year":"1984"},{"issue":"3","key":"e_1_2_1_12_1","first-page":"64A","article-title":"Distribution of cell bodies expressing substance P, enkephalin and dynorphin B in kitten and cat striatum","volume":"208","author":"Chesselet M.\u2010F.","year":"1984","journal-title":"Anat. Rec."},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901780108"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4615-8987-7_7"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4615-8987-7_7"},{"key":"e_1_2_1_16_1","first-page":"223","volume-title":"The Rat Nervous System. Vol. 1, Forebrain and Midbrain","author":"de Olmos J.","year":"1985"},{"key":"e_1_2_1_17_1","first-page":"995","article-title":"Distributions and relationships to each other of clusters of neurotensin and substance\u2010P immunoreactive neurons in the caudate\u2010putamen and ventral striatum of the rat in the early postnatal period","volume":"13","author":"Eggerman K.","year":"1987","journal-title":"Soc. Neurosci. Abstr."},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0143-4179(88)90081-9"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1982.tb05340.x"},{"key":"e_1_2_1_20_1","first-page":"355","volume-title":"Handbook of Chemical Neuroanatomy. Vol. 4, GABA and Neuropeptides in the CNS, Part I","author":"Emson P. C.","year":"1985"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902180106"},{"key":"e_1_2_1_22_1","first-page":"75","article-title":"The primate globus pallidus: A Golgi and electron microscopic study","volume":"15","author":"Fox C. A.","year":"1974","journal-title":"J. Hirnforsch."},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/0197-0186(86)90018-5"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/311461a0"},{"key":"e_1_2_1_25_1","first-page":"1327","article-title":"The developmental and biochemical basis of dual \u201cpatch\u201d and \u201cmatrix\u201d nigrostriatal dopaminergic systems in the rat","volume":"12","author":"Gerfen C. R.","year":"1986","journal-title":"Soc. Neurosci. Abstr."},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.07-12-03935.1987"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.07-12-03915.1987"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(83)90536-X"},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/307543a0"},{"key":"e_1_2_1_30_1","first-page":"413","article-title":"Increase of neurotensin content elicited by neuroleptics in nucleus accumbens","volume":"215","author":"Govoni S.","year":"1980","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"e_1_2_1_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(84)90293-8"},{"key":"e_1_2_1_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/9780470720882.ch7"},{"key":"e_1_2_1_33_1","first-page":"514","article-title":"Striatal cell bodies expressing dynorphin B\u2010like (DYN) and met\u2010enkephalin\u2010like (ENK) immunoreactivities have complementary distributions in kittens and contrasting distributions in cats","volume":"10","author":"Graybiel A. M.","year":"1984","journal-title":"Soc. Neurosci. Abstr."},{"key":"e_1_2_1_34_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.81.24.7980"},{"key":"e_1_2_1_35_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.75.11.5723"},{"key":"e_1_2_1_36_1","first-page":"427","volume-title":"Chemical Neuroanatomy","author":"Graybiel A. M.","year":"1983"},{"key":"e_1_2_1_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00238352"},{"key":"e_1_2_1_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(81)90131-7"},{"key":"e_1_2_1_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(81)90188-3"},{"key":"e_1_2_1_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902350304"},{"key":"e_1_2_1_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(83)90291-9"},{"key":"e_1_2_1_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(85)90272-6"},{"key":"e_1_2_1_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902080207"},{"key":"e_1_2_1_44_1","doi-asserted-by":"publisher","DOI":"10.1159\/000145824"},{"key":"e_1_2_1_45_1","first-page":"37","volume-title":"The Rat Nervous System","author":"Heimer L.","year":"1985"},{"key":"e_1_2_1_46_1","series-title":"Golgi Centennial Symposium Proceedings","first-page":"177","volume-title":"The subcortical projections of allocortex. Similarities in the neural associations of the hippocampus, the piriform cortex and the neocortex","author":"Heimer L.","year":"1975"},{"key":"e_1_2_1_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902550409"},{"key":"e_1_2_1_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(87)90268-5"},{"key":"e_1_2_1_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(84)90045-9"},{"key":"e_1_2_1_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/291415a0"},{"key":"e_1_2_1_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(77)90160-4"},{"key":"e_1_2_1_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902220407"},{"key":"e_1_2_1_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(80)90127-X"},{"key":"e_1_2_1_54_1","first-page":"379","article-title":"Projections of the bed nucleus of the stria terminalis to the mesencephalon, pons, and medulla oblongata in the cat","volume":"52","author":"Holstege G.","year":"1985","journal-title":"Exp. Brain Res."},{"key":"e_1_2_1_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(79)91013-8"},{"key":"e_1_2_1_56_1","first-page":"237","volume-title":"Cortical Integration","author":"Iversen S. D.","year":"1984"},{"key":"e_1_2_1_57_1","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/978-94-011-6302-6_12","volume-title":"The Neural Basis of Behavior","author":"Iversen S. D.","year":"1982"},{"key":"e_1_2_1_58_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902100302"},{"key":"e_1_2_1_59_1","first-page":"147","volume-title":"The Neurobiology of the Nucleus Accumbens","author":"Johansson O.","year":"1981"},{"key":"e_1_2_1_60_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.900350502"},{"key":"e_1_2_1_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-9781(81)80031-9"},{"key":"e_1_2_1_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(70)90312-4"},{"key":"e_1_2_1_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(77)90613-8"},{"key":"e_1_2_1_64_1","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/B978-0-12-154450-8.50029-X","volume-title":"Biochemistry of Taste and Olfaction","author":"Krieger N. R.","year":"1981"},{"key":"e_1_2_1_65_1","first-page":"117","volume-title":"Progress in Psychobiology and Physiological Psychology","author":"Mogenson G. F.","year":"1987"},{"key":"e_1_2_1_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(87)90350-2"},{"key":"e_1_2_1_67_1","first-page":"43","volume-title":"The Limbic System: Functional Organization and Clinical Disorders","author":"Nauta W. J. H.","year":"1986"},{"key":"e_1_2_1_68_1","doi-asserted-by":"publisher","DOI":"10.1002\/9780470720882.ch2"},{"key":"e_1_2_1_69_1","first-page":"136","volume-title":"The Hypothalamus","author":"Nauta W. J. H.","year":"1969"},{"key":"e_1_2_1_70_1","first-page":"283","article-title":"Neurotensin: Perchance an endogenous neuroleptic?","volume":"15","author":"Nemeroff C. B.","year":"1980","journal-title":"Biol. Psychiatry"},{"key":"e_1_2_1_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(80)90867-7"},{"key":"e_1_2_1_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(77)90173-1"},{"key":"e_1_2_1_73_1","first-page":"337","article-title":"Interactions of neurotensin with brain dopamine systems: Biochemical and behavioral studies","volume":"225","author":"Nemeroff C. B.","year":"1983","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"e_1_2_1_74_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901910203"},{"key":"e_1_2_1_75_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901910204"},{"key":"e_1_2_1_76_1","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/0014-2999(79)90090-6","article-title":"Centrally administered neurotensin: Activity in the Julow\u2010Courvoisier muscle relaxation test in mice","volume":"54","year":"1979","journal-title":"Eur. J. Pharmacol."},{"key":"e_1_2_1_77_1","first-page":"227","volume-title":"Comparative Neurobiology of the Basal Ganglia","author":"Parent A.","year":"1986"},{"key":"e_1_2_1_78_1","first-page":"516","article-title":"Enkephalin (EK), dynorphin (DYN), substance P (SP) and glutamic acid decarboxylase (GAD) in striatal efferents","volume":"10","author":"Paxinos G.","year":"1984","journal-title":"Soc. Neurosci. Abstr."},{"key":"e_1_2_1_79_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902380305"},{"key":"e_1_2_1_80_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01611860"},{"key":"e_1_2_1_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/0196-9781(82)90011-0"},{"key":"e_1_2_1_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(81)90556-4"},{"key":"e_1_2_1_83_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01474384"},{"key":"e_1_2_1_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(84)90379-3"},{"key":"e_1_2_1_85_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.02-10-01424.1982"},{"key":"e_1_2_1_86_1","first-page":"95","article-title":"The primate substantia nigra: A Golgi and electron microscopic study","volume":"15","author":"Schwyn R. C.","year":"1974","journal-title":"J. Hirnforsch."},{"key":"e_1_2_1_87_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1973.04200020023003"},{"key":"e_1_2_1_88_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902570307"},{"key":"e_1_2_1_89_1","doi-asserted-by":"crossref","first-page":"1891","DOI":"10.1016\/0306-4522(82)90005-7","article-title":"The globus pallidus and its rostroventral extension into the olfactory tubercle of the rat: Acyto\u2010 and chemoarchitectural study","volume":"1","author":"Switzer R. C.","year":"1982","journal-title":"Neuroscience"},{"key":"e_1_2_1_90_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1982.tb31565.x"},{"key":"e_1_2_1_91_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.74.9.4059"},{"key":"e_1_2_1_92_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902510106"},{"key":"e_1_2_1_93_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00236031"},{"key":"e_1_2_1_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(79)90042-6"},{"key":"e_1_2_1_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(81)90532-1"},{"key":"e_1_2_1_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(85)90302-1"},{"key":"e_1_2_1_97_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902430405"},{"key":"e_1_2_1_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(87)90337-5"},{"key":"e_1_2_1_99_1","first-page":"27","article-title":"The distribution and structure of labeled neurons and axon terminals in immunocytochemically defined striatal, pericommissural and subcommissural forebrain regions in the rat following injections of WGA\u2010HRP in the midbrain ventral tegmental area: LM of the TMB product and EM\/Golgi of its DAB\u2010CO++ stabilized counterpart","volume":"13","author":"Zahm D. S.","year":"1987","journal-title":"Soc. Neurosci. Abstr."},{"key":"e_1_2_1_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(85)90239-3"},{"key":"e_1_2_1_101_1","first-page":"199","article-title":"Regional specialization of the basal ganglia: The corticostriatopallidal system in the olfactory tubercle","volume":"11","author":"Zahm D. S.","year":"1985","journal-title":"Soc. Neurosci. Abstr."},{"key":"e_1_2_1_102_1","first-page":"152A","article-title":"The distribution of neurotensin immunoreactivity in relation to afferent and efferent projections of the ventral tegmental area","volume":"218","author":"Zahm D. S.","year":"1987","journal-title":"Anat. Rec."},{"key":"e_1_2_1_103_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902550410"},{"key":"e_1_2_1_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(85)90331-2"}],"container-title":["Journal of Comparative Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcne.902720406","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cne.902720406","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T05:10:50Z","timestamp":1695705050000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cne.902720406"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,6,22]]},"references-count":103,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1988,6,22]]}},"alternative-id":["10.1002\/cne.902720406"],"URL":"https:\/\/doi.org\/10.1002\/cne.902720406","archive":["Portico"],"relation":{},"ISSN":["0021-9967","1096-9861"],"issn-type":[{"value":"0021-9967","type":"print"},{"value":"1096-9861","type":"electronic"}],"subject":[],"published":{"date-parts":[[1988,6,22]]}}}