{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T06:54:43Z","timestamp":1774076083747,"version":"3.50.1"},"reference-count":53,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2004,10,9]],"date-time":"2004-10-09T00:00:00Z","timestamp":1097280000000},"content-version":"vor","delay-in-days":5913,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Comparative Neurology"],"published-print":{"date-parts":[[1988,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The distribution of neural inputs to the paraventricular (PVH) and supraoptic (SO) nuclei from the regions of the A1, the A2, and the A6 (locus coeruleus) noradrenergic cell groups was investigated by using a plant lectin, <jats:italic>Phaseolus vulgaris<\/jats:italic> leucoagglutinin (PHA\u2010L), as an anterogradely transported tracer. An immunofluorescence double\u2010labeling procedure was used to determine the extent to which individual anterogradely labeled fibers and terminals in the PVH and the SO also displayed immunoreactive dopamine\u2010\u03b2\u2010hydroxylase (DBH), a marker for catecholaminergic neurons. The results may be summarized as follows: (1) Projections from the A1 region were found primarily, and in some experiments almost exclusively, in those parts of the magnocellular division of the PVH and the SO known to contain vasopressinergic neurons. (2) Projections from the A2 region were distributed primarily throughout the parvicellular division of the PVH and were most dense in the dorsal medial part, a region known to contain a prominent population of corticotropin\u2010releasing factor (CRF)\u2010immunoreactive neurons. In addition, a less\u2010dense projection to the magnocellular division of the PVH and to the SO was consistently found. (3) Fibers originating from the locus coeruleus were distributed almost exclusively to the parvicellular division of the PVH, with the most prominent input localized to the periventricular zone, a part of the PVH known to contain dopamine\u2010, somatostatin\u2010, and thyrotropin\u2010releasing\u2010hormone\u2010containing neurons. We found no evidence for a projection from A6 to the SO. (4) The majority of fibers originating from the A1, the A2 or the A6 regions contained DBH immunoreactivity, although an appreciable number did not. These results suggest that each of the three brainstem noradrenergic cell groups that contribute to the innervation of the PVH and\/or the SO is in a position to modulate the activity of anatomically and chemically distinct groups of neurosecretory neurons.<\/jats:p>","DOI":"10.1002\/cne.902740107","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T18:54:56Z","timestamp":1104605696000},"page":"60-76","source":"Crossref","is-referenced-by-count":618,"title":["Anatomical specificity of noradrenergic inputs to the paraventricular and supraoptic nuclei of the rat hypothalamus"],"prefix":"10.1002","volume":"274","author":[{"suffix":"Jr.","given":"E. T.","family":"Cunningham","sequence":"first","affiliation":[]},{"given":"P. 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