{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T12:24:18Z","timestamp":1771071858708,"version":"3.50.1"},"reference-count":53,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2004,10,9]],"date-time":"2004-10-09T00:00:00Z","timestamp":1097280000000},"content-version":"vor","delay-in-days":5722,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Comparative Neurology"],"published-print":{"date-parts":[[1989,2,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Specific antibodies against gamma aminobutyric acid (GABA) and glutamic acid decarboxylase (GAD) were used to study the organization of the GABAergic system in the rat hippocampal formation. Both the number of GABA\u2010like\u2010immunoreactive (Li) somata and neuropil density were assessed in semithin sections. Cell counts revealed that approximately 11% of the hippocampal neuronal population showed GABA\u2010Li within the various planes of section.<\/jats:p><jats:p>Each layer in the hippocampal formation had a characteristic organization of GABA\u2010Li elements. In Ammon's horn, 80\u201395% of the neuronal somata within the apical and basal dendritic regions were GABA\u2010Li positive. Within the pyramidal cell layer 5\u20138% of the cells were GABA\u2010Li in the CA1 to CA3 subfields of Ammon's horn and only 3% were GABA\u2010Li within that portion of the pyramidal cell layer that inserts into the hilus. Only slight differences in the density of the GABA\u2010Li neuropil were observed within the CA1\u2010CA3 dendritic regions. Restricted to the stratum lucidum was a dense band of GABA\u2010Li label. Counts of immunoreactive grains localized on the perimeter of pyramidal (CA1\u2010CA3) and granule somata revealed more terminal boutons on the CA3 cells than on CA1 and granule neuronal somata.<\/jats:p><jats:p>A topographical distribution of GABA\u2010Li somata and neuropil was found in the fascia dentata: There the label particularly concerned its suprapyramidal and rostrolateral portions. Approximately 40% of neurons in the molecular layer, 60% in the polymorph layer, and 18% within the hilar region were GABA\u2010Li. Within the granule cell layer only 2% of the neurons were GABA\u2010Li positive. Distinct differences in the density of the GABA\u2010Li neuropil were present in the molecular, pericellular granular, and hilar regions of the fascia dentata.<\/jats:p><jats:p>While the morphology of GABA\u2010Li neuronal somata varied according to their hippocampal layer, the most heterogeneous cell types were found in the regio inferior of the hippocampus. There we have identified neurons that are reminiscent of the inferior region interneuron described in Golgi material by Amaral and Woodward (Brain Res. <jats:italic>124:<\/jats:italic>225\u2013236, '77). Moreover, particularly in the sagittal plane, we have identified oval, triangular, and round cells and that have processes oriented in a parallel arrangement, appearing to be aligned along the granule cell mossy fibers.<\/jats:p>","DOI":"10.1002\/cne.902800207","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T21:19:02Z","timestamp":1104614342000},"page":"254-271","source":"Crossref","is-referenced-by-count":184,"title":["Organization of the GABAergic system in the rat hippocampal formation: A quantitative immunocytochemical study"],"prefix":"10.1002","volume":"280","author":[{"given":"Walter","family":"Woodson","sequence":"first","affiliation":[]},{"given":"Liliana","family":"Nitecka","sequence":"additional","affiliation":[]},{"given":"Yehezkel","family":"Ben\u2010Ari","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2004,10,9]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1982.sp014255"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901820508"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901950106"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(77)90881-2"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4684-2976-3_7"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01208595"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1964.27.4.592"},{"key":"e_1_2_1_9_1","first-page":"113","volume-title":"GABA in Nervous System Function","author":"Barber R.","year":"1976"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901900107"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(85)90299-4"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(87)90793-1"},{"key":"e_1_2_1_13_1","first-page":"21","volume-title":"Neurobiology of the hippocampus","author":"Braitenberg V.","year":"1983"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00238387"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(81)90413-3"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/30.1.7033369"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(84)90431-2"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01258450"},{"key":"e_1_2_1_19_1","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/0006-8993(86)90984-4","article-title":"Gamma\u2010aminobutyric acid immunoreactivity in the rat hippocampus. 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