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The entire population of muscarinic receptors was labeled with [<jats:sup>3<\/jats:sup>H]quinuclidinyl\u2010benzilate; the M<jats:sub>1<\/jats:sub> receptor subtype was labeled with [<jats:sup>3<\/jats:sup>H]pirenzepine; and the density of the M<jats:sub>2<\/jats:sub> receptor subtype was estimated by subtracting the density of M<jats:sub>1<\/jats:sub> receptors from the total population. The overall density of M<jats:sub>1<\/jats:sub> and M<jats:sub>2<\/jats:sub> receptor subtypes was similar throughout the cerebral cortex. However, their laminar distribution varied regionally. In cortical regions of the parietal and occipital lobes and in the primary motor cortex of the frontal lobe, both M<jats:sub>1<\/jats:sub> and M<jats:sub>2<\/jats:sub> receptor subtypes were concentrated in the supragranular layers. By contrast, in prefrontal cortical areas, the combined population of M<jats:sub>1<\/jats:sub> and M<jats:sub>2<\/jats:sub> receptors was evenly distributed across the cortical layers, though M<jats:sub>1<\/jats:sub> receptors were most dense and M<jats:sub>2<\/jats:sub> receptors least dense in layer IV. The difference in the distribution of cholinergic receptors in the prefrontal cortex compared to other neocortical areas reveals a degree of chemoarchitectural specificity of this region with respect to cholinergic markers that has escaped immunohistochemical and other anatomical and functional techniques.<\/jats:p>","DOI":"10.1002\/cne.902890206","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T21:44:20Z","timestamp":1104615860000},"page":"247-259","source":"Crossref","is-referenced-by-count":36,"title":["Regional differences in the distribution of muscarinic cholinergic receptors in the macaque cerebral cortex"],"prefix":"10.1002","volume":"289","author":[{"given":"Michael S.","family":"Lidow","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dorothy W.","family":"Gallager","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pasko","family":"Rakic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia S.","family":"Goldman\u2010Rakic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,9]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"218","article-title":"Anticholinergic psychotometric agents","volume":"4","author":"Abood L. 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