{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T01:06:47Z","timestamp":1776733607077,"version":"3.51.2"},"reference-count":58,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2004,10,9]],"date-time":"2004-10-09T00:00:00Z","timestamp":1097280000000},"content-version":"vor","delay-in-days":5200,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Comparative Neurology"],"published-print":{"date-parts":[[1990,7,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The topography and interrelationship of striatofugal neurons have been examined using a double retrograde tracing paradigm to label striatopallidal and striatonigral neurons in the same neostriatum. The rostral globus pallidus and the rostral substantia nigra in the same hemisphere were injected simultaneously with fluorescent tracers in three monkeys. In addition, the caudal globus pallidus and the caudal substantia nigra were injected separately in a fourth and fifth monkey with a fluorescent dye and wheat germ agglutinin\u2010horseradish peroxidase (WGA\u2010HRP), respectively. Digitized plots of fluorescent dye\u2010labeled neurons revealed that large numbers of striatonigral projection neurons lie within both neostriatal nuclei, i.e., the caudate and putamen. Similarly, neurons innervating the globus pallidus were found in both caudate and putamen. The distribution of retrogradely labeled neurons observed was consistent with the topography of striatofugal projections that has been described previously, i.e., the rostrocaudal and mediolateral axes of the neostriatum are preserved in the striatopallidal and striatonigral projections (e.g., Szabo, '62, '67, 70, '72) and the dorsoventral axis is inverted in the projection of the neostriatum onto the nigra but not in the striatopallidal projection (Nauta and Domesick, '79; Gerfen, '85). Analysis of cases in which striatonigral and striatopallidal neurons were present in large numbers within the same region of the neostriatum disclosed that the two populations are intermingled such that small clusters of striatopallidal neurons are surrounded by striatonigral neurons and vice versa. The clustered arrangement of striatofugal neurons observed in the fluorescent cases was unambiguous in a case in which HRP was injected into the caudal substantia nigra. In this case, both anterogradely labeled terminals and retrogradely labeled neurons exhibited a striking, compartmental\u2010like distribution in the posterior putamen.<\/jats:p><jats:p>Our observations indicate that the matrix compartment of the neostriatum is comprised of a patchwork of interposed clusters of nigral and pallidal efferent neurons. We hypothesize that these clusters of efferent neurons may direct interdigitated cortical inputs into distinct nigro\u2010and pallido\u2010thalamic pathways. In view of the parallel nature of processing throughout the basal ganglia, it appears that convergence of these segregated nigral and pallidal loops must occur at the cortical level where prefrontal and premotor targets of the basal ganglia are interconnected via corticocortical projections (Selemon and Goldman\u2010Rakic, '88).<\/jats:p>","DOI":"10.1002\/cne.902970304","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T22:05:34Z","timestamp":1104617134000},"page":"359-376","source":"Crossref","is-referenced-by-count":101,"title":["Topographic intermingling of striatonigral and striatopallidal neurons in the rhesus monkey"],"prefix":"10.1002","volume":"297","author":[{"given":"L. D.","family":"Selemon","sequence":"first","affiliation":[]},{"given":"P. S.","family":"Goldman\u2010Rakic","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2004,10,9]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ne.09.030186.002041"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(86)90012-6"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901650402"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.29.5.426"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00248879"},{"key":"e_1_2_1_7_1","first-page":"1017","volume-title":"Handbook of Physiology, Sect. 1, The Nervous System","author":"DeLong M. R.","year":"1981"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00238104"},{"key":"e_1_2_1_9_1","first-page":"908","article-title":"Morphology of neurons in cell clusters in the caudato\u2010putamen and nucleus accumbens of the rat","volume":"15","author":"Domesick V. B.","year":"1989","journal-title":"Soc. Neurosci. Abst."},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(84)90127-7"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/311461a0"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902360404"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.07-12-03915.1987"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902770204"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901710305"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902050408"},{"key":"e_1_2_1_17_1","first-page":"373","volume-title":"Handbook of Physiology","author":"Goldman\u2010Rakic P. S.","year":"1987"},{"key":"e_1_2_1_18_1","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1146\/annurev.ne.11.030188.001033","article-title":"Topography of cognition: Parallel distributed networks in primate association cortex","volume":"11","author":"Goldman\u2010Rokic P. S.","year":"1988","journal-title":"Ann. Rev. Neurosci"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.75.11.5723"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00238352"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(81)90131-7"},{"key":"e_1_2_1_22_1","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/0006-8993(75)90550-8","article-title":"Identification of striatal and pallidal neurons projecting to the substantia nigr a. An experimental study by means of retrograde axonal transport of horseradish peroxidase","volume":"91","author":"Grofova I.","year":"1975","journal-title":"Brain Res."},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(82)91118-6"},{"key":"e_1_2_1_24_1","first-page":"904","article-title":"The organization of the efferent projections from the primate ventral pallidum","volume":"15","author":"Haber S. N.","year":"1989","journal-title":"Soc. Neurosci. Abst."},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/291415a0"},{"key":"e_1_2_1_26_1","first-page":"23A","article-title":"A new accurate method for stereotaxic surgery in monkeys","volume":"199","author":"Ilinsky L. A.","year":"1981","journal-title":"Anat. Rec."},{"key":"e_1_2_1_27_1","first-page":"563","article-title":"Stereotaxic surgery in the rhesus monkey (Macaca mulatta) utilizing intracerebral landmarks","volume":"45","author":"Ilinsky I. A.","year":"1982","journal-title":"Appl. Neurophysiol"},{"key":"e_1_2_1_28_1","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/BF00235822","article-title":"An autoradiographic study of topographical relationships between pallidal and cerebellar projections to the cat thalamus","volume":"54","author":"Ilinsky I. A.","year":"1984","journal-title":"Exp. Brain Res."},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902620303"},{"key":"e_1_2_1_30_1","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1002\/cne.902360304","article-title":"Organization of the nigrothalamocortical system in the rhesus monkey","volume":"236","author":"Ilinsky I. A.","year":"1985","journal-title":"J. Comp. Neurol."},{"key":"e_1_2_1_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00236173"},{"key":"e_1_2_1_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901690302"},{"key":"e_1_2_1_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(75)90384-4"},{"key":"e_1_2_1_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00237639"},{"key":"e_1_2_1_35_1","doi-asserted-by":"publisher","DOI":"10.1159\/000123779"},{"key":"e_1_2_1_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901510302"},{"key":"e_1_2_1_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(85)90363-4"},{"key":"e_1_2_1_38_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.06-12-03436.1986"},{"key":"e_1_2_1_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902510302"},{"key":"e_1_2_1_40_1","doi-asserted-by":"publisher","DOI":"10.1177\/26.2.24068"},{"key":"e_1_2_1_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-08-024408-2.50006-3"},{"key":"e_1_2_1_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(66)90103-X"},{"key":"e_1_2_1_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(84)91224-1"},{"key":"e_1_2_1_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(89)90047-5"},{"key":"e_1_2_1_45_1","first-page":"25","article-title":"An autoradiographic study of the striatofugal fibers in the, monkey","volume":"16","author":"Poirier L. J.","year":"1980","journal-title":"J. Neur. Trans., Suppl."},{"key":"e_1_2_1_46_1","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1523\/JNEUROSCI.04-02-00539.1984","article-title":"The origin of thalamic inputs to arcuate premotor and supplementary motor areas","volume":"4","author":"Schell G. R.","year":"1984","journal-title":"J. Neurosci."},{"key":"e_1_2_1_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(82)90177-9"},{"key":"e_1_2_1_48_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.05-03-00776.1985"},{"key":"e_1_2_1_49_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.08-11-04049.1988"},{"key":"e_1_2_1_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(86)90159-4"},{"key":"e_1_2_1_51_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00236276"},{"key":"e_1_2_1_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(62)90067-5"},{"key":"e_1_2_1_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(67)90166-5"},{"key":"e_1_2_1_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(70)90196-2"},{"key":"e_1_2_1_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(72)90099-4"},{"key":"e_1_2_1_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(86)91632-X"},{"key":"e_1_2_1_57_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901990205"},{"key":"e_1_2_1_58_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901150107"},{"key":"e_1_2_1_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(78)90059-8"}],"container-title":["Journal of Comparative Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcne.902970304","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cne.902970304","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T14:28:53Z","timestamp":1697984933000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cne.902970304"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,7,15]]},"references-count":58,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1990,7,15]]}},"alternative-id":["10.1002\/cne.902970304"],"URL":"https:\/\/doi.org\/10.1002\/cne.902970304","archive":["Portico"],"relation":{},"ISSN":["0021-9967","1096-9861"],"issn-type":[{"value":"0021-9967","type":"print"},{"value":"1096-9861","type":"electronic"}],"subject":[],"published":{"date-parts":[[1990,7,15]]}}}