{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T15:38:41Z","timestamp":1762270721497},"reference-count":62,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2004,10,9]],"date-time":"2004-10-09T00:00:00Z","timestamp":1097280000000},"content-version":"vor","delay-in-days":4240,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Comparative Neurology"],"published-print":{"date-parts":[[1993,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Six OFF\u2010alpha ganglion cells and a single OFF\u2010beta ganglion cell were penetrated with intracellular microelectodes and marked with horseradish peroxidase (HRP) in a perfused cat eyecup. Gaussian center radii (<jats:italic>R<\/jats:italic><jats:sub>c<\/jats:sub>) ranging from 40 to 217 \u03bcm were measured for receptive fields mapped with slits, values in agreement with previous extracellular reports. ON and OFF response components revealed nearly identical <jats:italic>R<\/jats:italic><jats:sub>c<\/jats:sub>'s and center locations. Although Gaussian diameters (2<jats:italic>R<\/jats:italic><jats:sub>c<\/jats:sub>) were about 80% of dendritic field diameters overall, in this sample dendritic and receptive fields were not well correlated. Spatial tuning of ganglion cells was evidenced in peaked amplitude\u2010vs.\u2010width functions, fit by difference\u2010of\u2010Guassians models. Such plots yielded <jats:italic>R<\/jats:italic><jats:sub>c<\/jats:sub> values about 40% less than position\u2010vs amplitude plots. <jats:italic>R<\/jats:italic><jats:sub>s<\/jats:sub> values for surrounds ranged from 200 to 1,700 \u03bcm.<\/jats:p><jats:p>Rod and cone signals were investigated with flicker. Rod flicker signals in OFF\u2010alpha cells were larger and of shorter latency than in either horizontal or AII amacrine cells. Cone flicker signals were also short in latency, with an ON response time constant of 9 msec, and an OFF response time constant of 3 msec. The OFF\u2010alpha rod\u2010cone transition involved a latency increase of 20\u201330 msec.<\/jats:p><jats:p>The spontaneous and light\u2010evoked impulse rates of OFF\u2010alpha responses varied linearly with extrinsic current, but the amplitude of ON hyperpolarization was little affected. After injection of staining current, the OFF\u2010beta cell transiently depolarized at ON, suggestive of ON inhibition with reversed chloride gradient, a result not seen in OFF\u2010alpha responses.<\/jats:p><jats:p>Events (peaked, depolarizing voltage fluctuations) of high, low, and intermediate amplitudes were studied in OFF\u2010alpha responses. High amplitude events (impulses), were OFF\u2010correlated with the stimulus, and exhibited mean rise times (transit time from 25 to 75% of peak amplitude) from 255 to 392 \u03bcsec. Intermediate level events (presumed synaptic origin) were also OFF correlated and had longer rise times (325 \u03bcsec to 1.56 msec). Low level events (234\u2013685 \u03bcsec) revealed either ON, ON\/OFF, or no stimulus correlation. Published in 1993 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/cne.903290106","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T20:59:17Z","timestamp":1104613157000},"page":"68-84","source":"Crossref","is-referenced-by-count":23,"title":["OFF\u2010alpha and OFF\u2010beta ganglion cells in cat retina. 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