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Of the four pharmacological classes of receptors that many mediate the actions of glutamate, the N\u2010methyl\u2010D\u2010aspartate (NMDA) type is of particular interest insofar as it has been implicated in the neural processes underlying long\u2010term synaptic plasticity as well as excitotoxic injury. NMDA ligand binding sites are abundant in the structures of the basal ganglia, and NMDA receptors have been linked to neuronal excitability, neuropeptide gene expression, and regulation of dopamine release in these regions. NMDA receptors are believed to be heterooligomers of subunits from two families: NMDAR1, encoded by a single gene but alternatively spliced to produce eight distinct isoforms (NMDAR1A\u2013H), and NMDAR2, encode by four separate genes (NMDAR2A\u2013D).<\/jats:p><jats:p>We have used in situ hydridization with a total of 13 oligonucleotide probes to examine the expression of these genes in the rat basal ganglia. NMDAR1 subunits are expressed throughout the basal ganglia as well as in the rest of the brain; however, the alternatively spliced amino\u2010terminal region Insertion I is abundantly expressed only in the subthalamic nucleus and is not detectable in the neostriatum, globus pallidus, or substantia nigra pars compacta. In contrast, expression of the carboxy terminus segment Deletion I is prominent in the striatum but is not observed in other elements of the basal ganglia. NMDAR2 subunits also exhibit differential expression: NMDAR2B is abundant in the striatum, but NMDAR2A is present within the striatum only at low levels. NMDAR2C is present in the substantia nigra pars compacta only, while NMDAR2D exhibits an unusual distribution, with high levels of expression in the substantia nigra pars compacta, the subthalamic nucleus, the globus pallidus, and the ventral pallidum.<\/jats:p><jats:p>Since each isoform of the NMDAR1 and NMDAR2 subunits can confer distinct properties on the resultant NMDA receptor, these data imply that there is a high degree of regional specialization in the properties of NMDA receptors within the basal ganglia. \u00a9 1994 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/cne.903430102","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T20:59:47Z","timestamp":1104613187000},"page":"1-16","source":"Crossref","is-referenced-by-count":304,"title":["Organization of N\u2010methyl\u2010D\u2010aspartate glutamate receptor gene expression in the basal ganglia of the rat"],"prefix":"10.1002","volume":"343","author":[{"given":"David G.","family":"Standaert","sequence":"first","affiliation":[]},{"given":"Claudia M.","family":"Testa","sequence":"additional","affiliation":[]},{"given":"Anne B.","family":"Young","sequence":"additional","affiliation":[]},{"suffix":"Jr.","given":"John B.","family":"Penney","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2004,10,9]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(84)90261-0"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.42.4.733"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0166-2236(89)90074-X"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199005033221807"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(92)90006-N"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2836(05)80360-2"},{"key":"e_1_2_1_8_1","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/0006-8993(92)90645-P","article-title":"Glutamate stimulation of tyrosine hydroxylase is mediated by NMDA receptors in the rat striatum","volume":"569","author":"Arias M. 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