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EnergyPlus is the flagship Department of Energy software that performs BEM for different types of buildings. The input to EnergyPlus can often extend in the order of a few thousand parameters that have to be calibrated manually by an expert for realistic energy modeling. This makes it challenging and expensive thereby making BEM unfeasible for smaller projects. In this paper, we describe the \u2018Autotune\u2019 research that employs machine learning algorithms to generate agents for the different kinds of standard reference buildings in the US building stock. The parametric space and the variety of building locations and types make this a challenging computational problem necessitating the use of supercomputers. Millions of EnergyPlus simulations are run on supercomputers that are subsequently used to train machine learning algorithms to generate agents. These agents, once created, can then run in a fraction of the time thereby allowing cost\u2010effective calibration of building models. Published 2014. This article is a US Government work and is in the public domain in the USA.<\/jats:p>","DOI":"10.1002\/cpe.3267","type":"journal-article","created":{"date-parts":[[2014,3,31]],"date-time":"2014-03-31T15:09:08Z","timestamp":1396278548000},"page":"2122-2133","source":"Crossref","is-referenced-by-count":19,"title":["Calibrating building energy models using supercomputer trained machine learning agents"],"prefix":"10.1002","volume":"26","author":[{"given":"Jibonananda","family":"Sanyal","sequence":"first","affiliation":[{"name":"Oak Ridge National Laboratory  One Bethel Valley Road, PO Box 2008, MS\u20106324 Oak Ridge TN 37831\u20106324 USA"}]},{"given":"Joshua","family":"New","sequence":"additional","affiliation":[{"name":"Oak Ridge National Laboratory  One Bethel Valley Road, PO Box 2008, MS\u20106324 Oak Ridge TN 37831\u20106324 USA"}]},{"given":"Richard E.","family":"Edwards","sequence":"additional","affiliation":[{"name":"Amazon.com, Inc., Wainrright (SEA 23)  535 Terry Ave N. Seattle WA 98109 USA"}]},{"given":"Lynne","family":"Parker","sequence":"additional","affiliation":[{"name":"The University of Tennessee in Knoxville  Min H. 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