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The contribution is devoted to the introduction of a CMOS implementation of a double\u2010scroll chaotic oscillator, which is designed by taking advantage of the intrinsic hyperbolic tangent\u2010type characteristic of the operational transconductance amplifier (OTA). The chaotic behavior of the CMOS oscillator is guaranteed by plotting the bifurcation diagram and evaluating the Lyapunov exponents. In this manner, a masking system based on CMOS chaotic systems is designed to protect privacy while transmitting ECG signals effectively. Basically, the chaotic time series is processed to generate pseudorandom signals in a continuous\u2010time domain. Mathematical modeling and simulation results under a UMC 180\u2010nm CMOS fabrication process demonstrate that the proposed masking system is well suited to provide hardware\u2010level security in the chaotic encryption of biomedical signals.<\/jats:p>","DOI":"10.1002\/cta.4500","type":"journal-article","created":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T22:23:12Z","timestamp":1741386192000},"page":"5802-5815","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["CMOS Design of a Chaos\u2010Based Masking System for Biomedical Signals Applications"],"prefix":"10.1002","volume":"53","author":[{"given":"Eduardo","family":"Ju\u00e1rez\u2010Mendoza","sequence":"first","affiliation":[{"name":"Department of Electronics Instituto Nacional de Astrof\u00edsica, \u00d3ptica y Electr\u00f3nica (INAOE)  Puebla Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregorio","family":"Zamora\u2010Mejia","sequence":"additional","affiliation":[{"name":"Consejo Nacional de Humanidades, Ciencia y Tecnologia (CONAHCyT)  Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7187-4686","authenticated-orcid":false,"given":"Esteban","family":"Tlelo\u2010Cuautle","sequence":"additional","affiliation":[{"name":"Department of Electronics Instituto Nacional de Astrof\u00edsica, \u00d3ptica y Electr\u00f3nica (INAOE)  Puebla Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"D\u00edaz\u2010S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Department of Electronics Instituto Nacional de Astrof\u00edsica, \u00d3ptica y Electr\u00f3nica (INAOE)  Puebla Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,3,4]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/e26090787"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1109\/JIOT.2023.3288560"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1109\/TII.2024.3403266"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mex.2024.102801"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/mi15030401"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1109\/TCSI.2023.3348695"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vlsi.2024.102258"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10470\u2010024\u201002278\u20109"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mee.2024.112194"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vlsi.2024.102165"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00034\u2010024\u201002833\u20109"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1109\/TCSI.2024.3434551"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1109\/TIE.2024.3417974"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matcom.2024.07.035"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1063\/1.166278"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevLett.71.65"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1109\/TCS.1983.1085395"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1109\/82.246162"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1109\/82.246161"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1142\/S0218127402006205"},{"key":"e_1_2_10_22_1","doi-asserted-by":"crossref","unstructured":"P.Ketthong C.Wannaboon W.San\u2010Um B.Srisuchinwong andT.Masayoshi \u201cA CMOS Chaotic Jerk Oscillator With Smoothly Balanced\u2010to\u2010Unbalanced Transition of Double\u2010Scroll Attractors \u201d in2016 Management and Innovation Technology International Conference (MITicon) (IEEE 2016).","DOI":"10.1109\/MITICON.2016.8025221"},{"key":"e_1_2_10_23_1","volume-title":"Digital Integrated Circuits: A Design Perspective","author":"Rabaey J. 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