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To effectively capture signals generated as target molecules pass through the nanopores, the readout circuit should be characterized with high bandwidth, high gain, low noise, and high throughput. However, parasitic capacitance limits the circuit stability and bandwidth. This paper presents a nanopore front\u2010end readout integrated chip, composed of a nanopore microelectrode chip and analog front\u2010end chips, adopting heterogeneous packaging technology and on\u2010chip circuit to minimize parasitic capacitance. The nanopore microelectrode chip is manufactured by micromanufacturing technology, where nanopores can be incorporated on it. The analog front\u2010end chips adopt resistive feedback trans\u2010impedance amplifiers and are taped out in 0.18\u2010\n m CMOS. Ultimately, a 16\u2010channel nanopore front\u2010end readout integrated chip is applied for biological nanopore sensing. After biological nanopores are incorporated, each channel of the nanopore front\u2010end readout integrated chip has bandwidth exceeding 11 kHz and equivalent input noise less than 3 pA. These characteristics enable effective detection of signals generated by target analytes passing through the biological nanopores.<\/jats:p>","DOI":"10.1002\/cta.4555","type":"journal-article","created":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T09:42:14Z","timestamp":1748338934000},"page":"6759-6771","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A High\u2010Bandwidth, Low\u2010Noise Front\u2010End Readout Integrated Chip for Nanopore"],"prefix":"10.1002","volume":"53","author":[{"given":"Ziran","family":"Xu","sequence":"first","affiliation":[{"name":"School of Electronic Science and Engineering Nanjing University  Nanjing China"}]},{"given":"Linlin","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Chemistry and Chemical Engineering Nanjing University  Nanjing China"}]},{"given":"Chenyu","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Electronic Science and Engineering Nanjing University  Nanjing China"}]},{"given":"Chengbing","family":"Zhong","sequence":"additional","affiliation":[{"name":"School of Chemistry and Chemical Engineering Nanjing University  Nanjing China"}]},{"given":"Nannan","family":"Wei","sequence":"additional","affiliation":[{"name":"School of Electronic Science and Engineering Nanjing University  Nanjing China"}]},{"given":"Yilun","family":"Ying","sequence":"additional","affiliation":[{"name":"School of Chemistry and Chemical Engineering Nanjing University  Nanjing China"}]},{"given":"Yitao","family":"Long","sequence":"additional","affiliation":[{"name":"School of Chemistry and Chemical Engineering Nanjing University  Nanjing China"}]},{"given":"Feng","family":"Yan","sequence":"additional","affiliation":[{"name":"School of Electronic Science and Engineering Nanjing University  Nanjing China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0933-8609","authenticated-orcid":false,"given":"Limin","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Electronic Science and Engineering Nanjing University  Nanjing China"}]}],"member":"311","published-online":{"date-parts":[[2025,4,18]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.24.13770"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41565-022-01193-2"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.1495"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/nn202253z"},{"key":"e_1_2_7_6_1","doi-asserted-by":"crossref","unstructured":"C.Dong Y.Jiang K.Jiang Y.Huang andY.Qin \u201cA 37.37\u03bcW\u2010per\u2010Cell Multifunctional Automated Nanopore Sequencing CMOS Platform With 16\u22178 Biosensor Array \u201d in2020 IEEE International Symposium on Circuits and Systems (ISCAS)(IEEE 2020) 1\u20134.","DOI":"10.1109\/ISCAS45731.2020.9181095"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1109\/JSEN.2022.3185457"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1063\/5.0180587"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1109\/TVLSI.2017.2654452"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1109\/JSEN.2021.3056443"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.7b00143"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ange.202013462"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/nn900441x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8FD00023A"},{"key":"e_1_2_7_15_1","doi-asserted-by":"crossref","unstructured":"M. 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