{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T13:51:44Z","timestamp":1761918704198,"version":"build-2065373602"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,4,13]],"date-time":"2005-04-13T00:00:00Z","timestamp":1113350400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Developmental Dynamics"],"published-print":{"date-parts":[[2005,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Despite recent progress, the precise mechanisms responsible for vertebrate cardiac development are still enigmatic. Better understanding of cardiac biology and disease necessitates identification and analysis of a full spectrum of regulatory and structural proteins specific to the developing heart. By performing an in silico screen, we identified a cardiac\u2010specific gene we named <jats:italic>Serdin1<\/jats:italic>. The <jats:italic>Serdin1<\/jats:italic> gene is conserved, and the message is restricted to the heart in several vertebrate species, thus implicating <jats:italic>Serdin1<\/jats:italic> as an important gene in cardiac development. In situ hybridization confirmed that the <jats:italic>Serdin1<\/jats:italic> message is cardiac\u2010specific in mice as early as embryonic day 8.5. Antibody staining demonstrated predominantly nuclear staining in immortalized cardiac cell lines (P19 and HL\u20101) and proliferating cultured cardiomyocytes, whereas in vivo SERDIN1 localizes to I bands of the sarcomere. Seven kilobases of the upstream regulatory sequence of <jats:italic>Serdin1<\/jats:italic> is sufficient for cardiac\u2010specific expression. Computer analysis revealed an 80\u2010bp homologous region between the mouse and the human <jats:italic>Serdin<\/jats:italic> genes that contains GATA, SRF, and MEF sites. Cardiac specificity and localization patterns suggest that SERDIN1 is intimately integrated with the molecular pathways controlling cardiogenesis in vertebrates. Developmental Dynamics 233:540\u2013552, 2005. \u00a9 2005 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/dvdy.20368","type":"journal-article","created":{"date-parts":[[2005,4,13]],"date-time":"2005-04-13T17:47:17Z","timestamp":1113414437000},"page":"540-552","source":"Crossref","is-referenced-by-count":18,"title":["Expression and regulation of mouse SERDIN1, a highly conserved cardiac\u2010specific leucine\u2010rich repeat protein"],"prefix":"10.1002","volume":"233","author":[{"given":"Igor I.","family":"Adameyko","sequence":"first","affiliation":[]},{"given":"Ryan E.","family":"Mudry","sequence":"additional","affiliation":[]},{"given":"Nga Rewa M.","family":"Houston\u2010Cummings","sequence":"additional","affiliation":[]},{"given":"Alexander P.","family":"Veselov","sequence":"additional","affiliation":[]},{"given":"Carol C.","family":"Gregorio","sequence":"additional","affiliation":[]},{"given":"Sergei G.","family":"Tevosian","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2005,4,13]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0177(2000)9999:9999<::AID-DVDY1049>3.0.CO;2-0"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1471-4906(03)00242-4"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000027865.61704.32"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1082"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1754.1994.tb00691.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.86.1.59"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4615-4267-4_3"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.6.2979"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/embo-reports\/kvd092"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI20408"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.00998"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/prot.10605"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.00824"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.00953"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.146.3.631"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.79.1.4"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/5976"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002727-200211000-00004"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2004.01.003"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.12.17.2748"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1110103"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.152302499"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI18937"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s001090050182"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcm.2003.09.005"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.3.950"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80885-5"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(01)00404-4"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00986.2003"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1136\/heart.85.4.438"}],"container-title":["Developmental Dynamics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fdvdy.20368","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/anatomypubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dvdy.20368","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T22:01:50Z","timestamp":1760392910000},"score":1,"resource":{"primary":{"URL":"https:\/\/anatomypubs.onlinelibrary.wiley.com\/doi\/10.1002\/dvdy.20368"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,4,13]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2005,6]]}},"alternative-id":["10.1002\/dvdy.20368"],"URL":"https:\/\/doi.org\/10.1002\/dvdy.20368","archive":["Portico"],"relation":{},"ISSN":["1058-8388","1097-0177"],"issn-type":[{"type":"print","value":"1058-8388"},{"type":"electronic","value":"1097-0177"}],"subject":[],"published":{"date-parts":[[2005,4,13]]}}}