{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T07:22:18Z","timestamp":1779261738288,"version":"3.51.4"},"reference-count":42,"publisher":"Wiley","issue":"4-5","license":[{"start":{"date-parts":[[2005,2,6]],"date-time":"2005-02-06T00:00:00Z","timestamp":1107648000000},"content-version":"vor","delay-in-days":6246,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dev. Genet."],"published-print":{"date-parts":[[1988,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The functional interaction of surface cAMP receptors with effector enzymes via G\u2010proteins was investigated in <jats:italic>Dictyostelium discoideum.<\/jats:italic> Several experimental conditions were used to investigate signal transduction, such as reduced temperatures, use of down\u2010regulated cells and of mutants. The results are presented as a model describing the complex interaction between multiple forms of the surface cAMP receptor and different G\u2010proteins that are responsible for the generation of the second messengers, cAMP, cGMP, InsP<jats:sub>3<\/jats:sub> and Ca<jats:sup>2+<\/jats:sup>.<\/jats:p>","DOI":"10.1002\/dvg.1020090404","type":"journal-article","created":{"date-parts":[[2005,5,25]],"date-time":"2005-05-25T22:21:40Z","timestamp":1117059700000},"page":"215-226","source":"Crossref","is-referenced-by-count":24,"title":["G\u2010proteins in the signal\u2010transduction pathways of <i>Dictyostelium discoideum<\/i>"],"prefix":"10.1002","volume":"9","author":[{"given":"B.","family":"Ewa Snaar\u2010Jagalska","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fanja","family":"Kesbeke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter J. M.","family":"Van Haastert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,2,6]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvg.1020030403"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.80.2.300"},{"key":"e_1_2_1_4_1","first-page":"55","article-title":"Cyclic nucleotides and cell\u2010cell communication in Dictyostelium discoideum","volume":"15","author":"Devreotes PN","year":"1983","journal-title":"Adv Cyclic Nucleotide Res"},{"key":"e_1_2_1_5_1","doi-asserted-by":"crossref","first-page":"6378","DOI":"10.1016\/S0021-9258(18)88983-9","article-title":"Kinetics and concentration dependence of reversible cAMP\u2010induced modification of the surface cAMP receptor in Dictyostelium","volume":"260","author":"Devreotes PN","year":"1985","journal-title":"J Biol Chem"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(85)80530-5"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(85)91395-6"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.86.2.537"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.86.2.545"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.86.2.554"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(85)91731-0"},{"key":"e_1_2_1_12_1","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1242\/jcs.87.4.513","article-title":"GTP analogues stimulate inositol triphosphate formation in Dictyostelium","volume":"87","author":"Europe\u2010Finner GN","year":"1987","journal-title":"J Cell Sci"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bi.56.070187.004225"},{"key":"e_1_2_1_14_1","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1128\/mr.51.4.396-418.1987","article-title":"Molecular basis of transmembrane signal transduction in Dictyostelium discoideum","volume":"51","author":"Janssens PMW","year":"1987","journal-title":"Microbiol Rev"},{"key":"e_1_2_1_15_1","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/S0021-9258(19)70017-9","article-title":"Photoaffinity labeling of the cell surface adenosine 3\u2032:5\u2032\u2010monophosphate receptor of Dictyostelium discoideum and its modification in down\u2010regulated cells","volume":"256","author":"Juliani MH","year":"1981","journal-title":"J Biol Chem"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0167-4889(85)90149-1"},{"key":"e_1_2_1_17_1","unstructured":"KesbekeF Snaar\u2010JagalskaBE Van HaastertPJM(1988): Signal transduction in Dictyostelium fgd A mutants with a defective interaction between surface cAMP receptors and a GTP\u2010binding regulatory protein.J Cell Biol(in press)."},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(77)90227-6"},{"key":"e_1_2_1_19_1","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1016\/S0021-9258(18)89658-2","article-title":"Identification and cyclic AMP\u2010induced modification of the cyclic AMP receptor Dictyostelium discoideum","volume":"260","author":"Klein P","year":"1985","journal-title":"J Biol Chem"},{"key":"e_1_2_1_20_1","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/S0021-9258(19)75934-1","article-title":"Purification of the surface cAMP receptor in Dictyostelium","volume":"261","author":"Klein P","year":"1987","journal-title":"J. Biol Chem"},{"key":"e_1_2_1_21_1","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/S0021-9258(19)75935-3","article-title":"The surface cyclic AMP receptor in Dictyostelium. Levels of ligand\u2010induced phosphorylation, solubilization, identification of primary transcript, and developmental regulation of expression","volume":"262","author":"Klein P","year":"1987","journal-title":"J Biol Chem"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.58.3.1152"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.74.6.2348"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(78)80311-1"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.83.2.265"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(76)80429-2"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.81.7.2122"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(86)90072-2"},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(86)81426-0"},{"key":"e_1_2_1_30_1","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1016\/S0021-9258(19)35437-7","article-title":"Ligand\u2010induced modification of a surface cAMP receptor of Dictyostelium discoideum does not require its occupancy","volume":"263","author":"Snaar\u2010Jagalska BE","year":"1987","journal-title":"J Biol Chem"},{"key":"e_1_2_1_31_1","doi-asserted-by":"crossref","unstructured":"Snaar\u2010JagalskaBE Van HaastertPJM(1988): Dictyostelium discoideum mutant synag 7 with altered G\u2010protein adenylate cyclase interaction.J Cell Sci(in press).","DOI":"10.1242\/jcs.91.2.287"},{"key":"e_1_2_1_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(88)80405-8"},{"key":"e_1_2_1_33_1","doi-asserted-by":"crossref","unstructured":"Snaar\u2010JagalskaBE JakobsKH Van HaastertPJM(1988b): Agonist\u2010stimulated high affinity GTP\u2010ase in Dictyostelium membranes.FEBS Lett(in press).","DOI":"10.1016\/0014-5793(88)80302-8"},{"key":"e_1_2_1_34_1","doi-asserted-by":"crossref","first-page":"15121","DOI":"10.1016\/S0021-9258(18)66840-1","article-title":"Surface receptor\u2010mediated activation of adenylate cyclase in wild\u2010type cells and aggregation deficient mutants","volume":"261","author":"Theibert A","year":"1986","journal-title":"J Biol Chem"},{"key":"e_1_2_1_35_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.96.2.347"},{"key":"e_1_2_1_36_1","doi-asserted-by":"crossref","first-page":"13321","DOI":"10.1016\/S0021-9258(18)90697-6","article-title":"Demonstration of receptor heterogeneity and negative cooperativity by nonequilibrium binding experiments. The cell surface cAMP receptor of Dictyostelium discoideum","volume":"259","author":"Van Haastert PJM","year":"1984","journal-title":"J Biol Chem"},{"key":"e_1_2_1_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(84)91596-1"},{"key":"e_1_2_1_38_1","doi-asserted-by":"crossref","first-page":"6904","DOI":"10.1016\/S0021-9258(19)62702-X","article-title":"G\u2010protein mediated interconversions of cell surface cAMP receptors and their involvement in excitation and desensitization of guanylate cyclase in Dictyostelium discoideum","volume":"261","author":"Van Haastert PJM","year":"1986","journal-title":"J Biol Chem"},{"key":"e_1_2_1_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1987.tb10592.x"},{"key":"e_1_2_1_40_1","doi-asserted-by":"crossref","first-page":"7700","DOI":"10.1016\/S0021-9258(18)47624-7","article-title":"Down\u2010regulation of cell surface cyclic AMP receptors and desensitization of cyclic AMP\u2010stimulated adenylate cyclase by cyclic AMP in Dictyostelium discoideum","volume":"262","author":"Van Haastert PJM","year":"1987","journal-title":"J Biol Chem"},{"key":"e_1_2_1_41_1","doi-asserted-by":"crossref","first-page":"7705","DOI":"10.1016\/S0021-9258(18)47625-9","article-title":"Adenosine 3\u2032,5\u2032\u2010monophosphorothioate (Rp\u2010isomer) induces down\u2010regulation of surface cyclic AMP receptors without receptor activation in Dictyostelium discoideum","volume":"262","author":"Van Haastert PJM","year":"1987","journal-title":"J Biol Chem"},{"key":"e_1_2_1_42_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.105.5.2301"},{"key":"e_1_2_1_43_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi00397a047"}],"container-title":["Developmental Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fdvg.1020090404","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dvg.1020090404","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,31]],"date-time":"2023-08-31T06:48:14Z","timestamp":1693464494000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dvg.1020090404"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,1]]},"references-count":42,"journal-issue":{"issue":"4-5","published-print":{"date-parts":[[1988,1]]}},"alternative-id":["10.1002\/dvg.1020090404"],"URL":"https:\/\/doi.org\/10.1002\/dvg.1020090404","archive":["Portico"],"relation":{},"ISSN":["0192-253X","1520-6408"],"issn-type":[{"value":"0192-253X","type":"print"},{"value":"1520-6408","type":"electronic"}],"subject":[],"published":{"date-parts":[[1988,1]]}}}