{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T17:38:19Z","timestamp":1771004299154,"version":"3.50.1"},"reference-count":49,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,2,6]],"date-time":"2005-02-06T00:00:00Z","timestamp":1107648000000},"content-version":"vor","delay-in-days":4419,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dev. Genet."],"published-print":{"date-parts":[[1993,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Differentiation inhibiting activity\/leukaemia inhibitory factor (DIA\/LIF) is a pleiotropic cytokine which has been implicated in a variety of developmental and physiological processes in mammals due to its broad range of biological activities in vitro. A role in very early development is suggested by the requirement for DIA\/ LIF to support the self\u2010renewal of cultured embryonic stem (ES) cells. Other data point to potential roles in the establishment and maintenance of primordial germ cells, in osteogenesis and in haematopoiesis, and possibly in neuronal specification. DIA\/LIF may also act as a mediator of the hepatic acute phase response. In the present study the expression of DIA\/LIF transcripts during murine development and in adult mice has been determined using a highly sensitive ribonuclease protection analysis. In contrast to previous reports, it is apparentthat DIA\/LIF transcripts are present at low levels in many adult mouse tissues. Higher levels of expression are observed in skin, lung, intestine, and uterus. Elevated amounts of mRNA are also found in certain foetal tissues during late gestation and neonatally. In earlier embryogenesis, however, DIA\/LIF mRNA is produced primarily in extraembryonic tissues. The alternative transcripts which produce either soluble or matrix\u2010associated DIA\/LIF exhibit overlapping but non\u2010identical patterns of expression, consistent with the proposition that the two isoforms may have distinct biological functions. These findings are suggestive of widespread roles for DIA\/LIF in vivo and are discussed in the light of available data on the phenotype of homozygous DIA\/LIF\u2010deficient mice. \u00a9 1993Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/dvg.1020140303","type":"journal-article","created":{"date-parts":[[2005,5,25]],"date-time":"2005-05-25T22:36:31Z","timestamp":1117060591000},"page":"165-173","source":"Crossref","is-referenced-by-count":42,"title":["Expression of alternative forms of differentiation inhibiting activity (DIA\/LIF) during murine embryogenesis and in neonatal and adult 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