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Genet."],"published-print":{"date-parts":[[1995,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We present evidence for the essential homology of four nuclear organelles that have previously been described under four different names: coiled bodies in mammalian somatic nuclei, prenucleolar bodies in nuclei assembled in vitro in <jats:italic>Xenopus<\/jats:italic> egg extract, sphere organelles in amphibian germinal vesicles (GVs), and Binnenk\u00f6rper in insect GVs. Each of these organelles contains coilin or a coilin\u2010related protein plus a variety of small nuclear ribonucleoproteins. We suggest that the sphere organelle\/coiled body is a \u201cuniversal\u201d nuclear component in the sense that it is involved in common nuclear processes and hence will be found in one form or another in most eukaryotic cells. We postulate that it functions in the assembly and sorting of snRNP complexes for three RNA processing pathways: pre\u2010mRNA splicing, rRNA processing, and histone pre\u2010mRNA 3\u2032 end formation. Specifically, the sphere organelle\/coiled body may be the initial site for assembly of processing complexes, which are then sorted to other places in the nucleus, where the actual RNA processing takes place. \u00a9 1995 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/dvg.1020160107","type":"journal-article","created":{"date-parts":[[2005,5,25]],"date-time":"2005-05-25T22:42:23Z","timestamp":1117060943000},"page":"25-35","source":"Crossref","is-referenced-by-count":112,"title":["Is the sphere organelle\/coiled body a universal nuclear component?"],"prefix":"10.1002","volume":"16","author":[{"given":"Joseph G.","family":"Gall","sequence":"first","affiliation":[]},{"given":"Alexander","family":"Tsvetkov","sequence":"additional","affiliation":[]},{"given":"Zheng'An","family":"Wu","sequence":"additional","affiliation":[]},{"given":"Christine","family":"Murphy","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2005,2,6]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.173.6.1407"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.5.1947"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.5.6.633"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.118.6.1297"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00331114"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4827(92)90068-J"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00333990"},{"key":"e_1_2_1_9_1","first-page":"129","article-title":"Un sencillo metodo de coloracion seletiva del reticulo protoplasmatico y sus efectos en los diversos organos nerviosos de vertebrados e invertebrados","volume":"2","author":"Cajal SR","year":"1903","journal-title":"Trab Lab Invest Biol (Madrid)"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-82792-1_1"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00357056"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00365156"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1991.tb07936.x"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.117.1.1"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.120.4.841"},{"key":"e_1_2_1_16_1","first-page":"191","article-title":"La v\u00e9sicule germinative et les globules polaires chez les batraciens: I. 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