{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T16:19:15Z","timestamp":1762100355610},"reference-count":60,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,2,6]],"date-time":"2005-02-06T00:00:00Z","timestamp":1107648000000},"content-version":"vor","delay-in-days":3689,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dev. Genet."],"published-print":{"date-parts":[[1995,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We report the cloning of full\u2010length cDNAs for a plasminogen\u2010related growth factor, hepatocyte growth factor\/scatter factor (HGF\/SF), its tyrosine kinase receptor, c\u2010met, and a close member of the same family, hepatocyte growth factor\u2010like\/macrophage stimulating protein (HGFI\/MSP), from the chick. We have used these cDNAs to provide the first report of the expression of this family of growth factors and the c\u2010met receptor at early stages of vertebrate development. RNAase protection and wholemount in situ hyb ridization were used on chick embryos between formation of the primitive streak and early organogenesis. We find patterns of expression for HGF\/SF and its receptor c\u2010met consistent with their known roles in ep ithelial\u2010mesenchymal transformation and angiogenesis. In addition, these genes and HGFI\/MSP are expressed in discrete locations within developing somites, suggesting a role in paraxial mesodermal development. Very strong and early expression of HGF\/SF in the elevating limb buds suggests its involvement in limb outgrowth. HGFI\/MSP is expressed in the notochord and then in the prospective floor plate region and could play a role in development of the neural tube. Interestingly, c\u2010met is often more closely as sociated with HGFI\/MSP than with its known ligand, HGF\/SF, raising the possibility that c\u2010met expression may be induced by HGFI\/MSP. \u00a9 1995 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/dvg.1020170110","type":"journal-article","created":{"date-parts":[[2005,5,25]],"date-time":"2005-05-25T22:44:49Z","timestamp":1117061089000},"page":"90-101","source":"Crossref","is-referenced-by-count":79,"title":["Expression of HGF\/SF, HGFI\/MSP, and c\u2010met suggests new functions during early chick development"],"prefix":"10.1002","volume":"17","author":[{"given":"Clotilde","family":"Th\u00e9ary","sequence":"first","affiliation":[]},{"given":"Melanie J.","family":"Sharpe","sequence":"additional","affiliation":[]},{"given":"Sarah J.","family":"Batley","sequence":"additional","affiliation":[]},{"given":"Claudio D.","family":"Stern","sequence":"additional","affiliation":[]},{"given":"Ermanno","family":"Gherardi","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2005,2,6]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"12846","DOI":"10.1016\/S0021-9258(18)99953-9","article-title":"Hepatocyte growth factor (HGF) receptor expression is inducible and is part of the delayed\u2010early response to HGF","volume":"269","author":"Boccaccio C","year":"1994","journal-title":"J Biol Chem"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1846706"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.119.3.629"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(87)90021-2"},{"key":"e_1_2_1_6_1","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1242\/dev.116.2.387","article-title":"The presence of hepatocyte growth factor in the developing rat","volume":"116","author":"de Frances MC","year":"1992","journal-title":"Development"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi00104a030"},{"key":"e_1_2_1_8_1","first-page":"1997","article-title":"Expression of the Met\/HGF receptor in normal and neoplastic human tissues","volume":"6","author":"Di Renzo MF","year":"1991","journal-title":"Oncogene"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1990.tb07454.x"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/pro.5560031222"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1994.tb06659.x"},{"key":"e_1_2_1_12_1","first-page":"31","volume-title":"Hepatocyte Growth Factor\u2010Scatter Factor (HGF\u2010SF) and the c\u2010Met Receptor","author":"Gherardi E","year":"1993"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/339155a0"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.5.1937"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmor.1050880104"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi00104a029"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/18.10.2961"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-1119(88)90330-7"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.13.6140"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V83.11.3160.3160"},{"key":"e_1_2_1_21_1","first-page":"255","article-title":"Polarity and patterning in the neural tube: The origin and function of the floor plate of the neural tube. 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