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In the spleen, two populations of effector cells were defined \u2013 one population consisted of phagocytic cells which were responsible for the onset of initial rapid lysis. A second population of cells, lymphocytes, were responsible for lysis, which proceeded at a slower, but continuous rate. Purified lymph node and thymus cells contained only the latter population. Both effector cell populations required the presence of an intact Fc piece on the target cell\u2010bound antibody molecule for lysis to proceed. Antibody\u2010mediated lymphocyte cytotoxicity appeared to be specific and required cell\u2010to\u2010cell contact.<\/jats:p>","DOI":"10.1002\/eji.1830020507","type":"journal-article","created":{"date-parts":[[2007,2,27]],"date-time":"2007-02-27T22:06:53Z","timestamp":1172614013000},"page":"419-424","source":"Crossref","is-referenced-by-count":48,"title":["Antibody\u2010mediated target cell lysis by non\u2010immune cells. 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