{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T22:07:30Z","timestamp":1759702050823},"reference-count":29,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2005,11,22]],"date-time":"2005-11-22T00:00:00Z","timestamp":1132617600000},"content-version":"vor","delay-in-days":11801,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[1973,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cortisone\u2010resistant thymocytes, spleen cells, thoracic duct lymphocytes, peritoneal exudate cells and peripheral blood lymphocytes of BALB\/c mice were immunized <jats:italic>in vitro<\/jats:italic> against syngeneic HPC\u2010108 plasma cell tumor cells. Cocultivation of spleen lymphocytes together with HPC\u2010108 cells generated the highest cytotoxic immune response in comparison to other lymphocyte sources. Cytotoxicity was tested in a 6 hour <jats:sup>51<\/jats:sup>Cr release assay using HPC\u2010108 cells as target cells.<\/jats:p><jats:p>The use of AKR anti\u2010\u03b8 C3H serum indicated that thymus\u2010derived (T) lymphocytes are essential to the initiation phase of the immune response to plasma cell tumor cells. Furthermore, evidence is presented that the cytotoxic effector cells in the <jats:italic>in vitro<\/jats:italic> tumor immune response are T lymphocytes.<\/jats:p><jats:p>Spleen cells activated <jats:italic>in vitro<\/jats:italic> against HPC\u2010108 tumor cells were shown to specifically prevent tumor growth from simultaneously injected HPC\u2010108 cells in irradiated recipient mice.<\/jats:p>","DOI":"10.1002\/eji.1830030804","type":"journal-article","created":{"date-parts":[[2007,2,27]],"date-time":"2007-02-27T23:36:50Z","timestamp":1172619410000},"page":"471-476","source":"Crossref","is-referenced-by-count":24,"title":["<i>In vitro<\/i> induction of tumor specific immunity: requirements for T lymphocytes and tumor growth inhibition <i>in vivo<\/i>"],"prefix":"10.1002","volume":"3","author":[{"given":"M.","family":"R\u00f6llinghoff","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Wagner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,22]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"457","volume":"20","author":"Klein E.","year":"1960","journal-title":"Cancer Res."},{"key":"e_1_2_1_3_2","first-page":"825","volume":"36","author":"Rosenau W.","year":"1966","journal-title":"J. Nat. Cancer Inst."},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1962.tb26446.x"},{"key":"e_1_2_1_5_2","first-page":"473","volume":"44","author":"Zbar B.","year":"1970","journal-title":"J. Nat. Cancer Inst."},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830030408"},{"key":"e_1_2_1_7_2","first-page":"90","volume":"8","author":"Koldowsky P.","year":"1960","journal-title":"Folia Biol. Prague"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/newbio241053a0"},{"key":"e_1_2_1_9_2","first-page":"338","volume":"16","author":"Corer P. A.","year":"1956","journal-title":"Cancer Res."},{"key":"e_1_2_1_10_2","first-page":"217","volume-title":"Handbook of Cell and Organ Culture","author":"Merchant D. J.","year":"1960"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.128.4.801"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(67)90393-5"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.129.3.591"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0008-8749(72)90246-8"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0008-8749(72)90004-4"},{"key":"e_1_2_1_16_2","first-page":"501","volume":"18","author":"Brunner K. T.","year":"1970","journal-title":"Immunology"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.120.3.413"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-197007000-00027"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/227072a0"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.147.3660.873"},{"key":"e_1_2_1_21_2","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1038\/newbio232080a0","volume":"232","author":"Harding B.","year":"1971","journal-title":"Nature\u2010New Biol."},{"key":"e_1_2_1_22_2","first-page":"619","volume":"122","author":"Allison A. C.","year":"1972","journal-title":"Ann. Inst. Pasteur"},{"key":"e_1_2_1_23_2","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1093\/jnci\/50.1.159","volume":"50","author":"R\u00f6llinghoff M.","year":"1973","journal-title":"J. Nat. Cancer Inst."},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/228620a0"},{"key":"e_1_2_1_25_2","first-page":"615","volume":"23","author":"Evans R.","year":"1972","journal-title":"Immunology"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830020110"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830020420"},{"key":"e_1_2_1_28_2","first-page":"21","volume":"243","author":"R\u00f6llinghoff M.","year":"1973","journal-title":"Nature\u2010New Biol."},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.131.2.235"},{"key":"e_1_2_1_30_2","unstructured":"Wagner H. Science1973 in press."}],"container-title":["European Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Feji.1830030804","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/eji.1830030804","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,2]],"date-time":"2023-11-02T06:32:24Z","timestamp":1698906744000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/eji.1830030804"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1973,8]]},"references-count":29,"journal-issue":{"issue":"8","published-print":{"date-parts":[[1973,8]]}},"alternative-id":["10.1002\/eji.1830030804"],"URL":"https:\/\/doi.org\/10.1002\/eji.1830030804","archive":["Portico"],"relation":{},"ISSN":["0014-2980","1521-4141"],"issn-type":[{"value":"0014-2980","type":"print"},{"value":"1521-4141","type":"electronic"}],"subject":[],"published":{"date-parts":[[1973,8]]}}}