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On the basis of a series of <jats:italic>in vitro<\/jats:italic> cell depletion techniques including glass absorption, removal of Fc receptor\u2010bearing cells and lysis of thymus\u2010dependent lymphocytes with a cytotoxic rabbit anti\u2010thymus cell sera, the predominant effector cell in this situation appears to be a thymus\u2010dependent lymphocyte. The main difference from previous published studies in mice appears to be the more rapid evolution of cytotoxic activity in the rat and the difficulty in detecting marked cytotoxic activity in the thoracic duct cells. Determination of the antigenic specificity of these cytotoxic cells by an inhibition assay suggests that their specificity is directed solely to transplantation antigens on the tumor cell.<\/jats:p>","DOI":"10.1002\/eji.1830031203","type":"journal-article","created":{"date-parts":[[2007,2,27]],"date-time":"2007-02-27T22:43:05Z","timestamp":1172616185000},"page":"748-754","source":"Crossref","is-referenced-by-count":4,"title":["Thymus\u2010dependent cytotoxic lymphocytes in the rat"],"prefix":"10.1002","volume":"3","author":[{"given":"P.","family":"Hersey","sequence":"first","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2008,4,16]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"501","volume":"18","author":"Brunner K. T.","year":"1970","journal-title":"Immunology"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/2281308a0"},{"key":"e_1_2_1_4_2","first-page":"761","volume":"45","author":"Canty T. G.","year":"1970","journal-title":"J. Nat. 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