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Double fluorochrome and mixed fluorochrome\u2010rosette tests were used to determine cellular specificity and interrelationship of cells bearing the different markers and the results confirmed by a variety of cell separation procedures. Anti\u2010brain antisera were, after appropriate absorption, T cell\u2010specific and identified the same population as that forming rosettes with sheep erythrocytes. This T cell population was quite distinct from those cells, presumably B lymphcytes, with cell surface immunoglobulin readily demonstrable by fluorescence. A small proportion of \u201clymphoid\u201d cells (\u201cnull\u201d cells) lacked all three markers. Heat\u2010aggregated human IgG (AggHIgG) was also used as a presumptive B cell marker and the results indicate that although most B lymphocytes do bind AggHIgG, presumably via an Fc receptor, a small proportion of thymocytes and presumptive T cells in tonsils also appear to possess a similar receptor. Almost all of these cells in tonsil were in fact lymphoblasts, thus raising the possibility that an Fc receptor is exposed or expressed on T lymphocytes when these cells are activated.<\/jats:p>","DOI":"10.1002\/eji.1830040414","type":"journal-article","created":{"date-parts":[[2007,2,28]],"date-time":"2007-02-28T00:11:06Z","timestamp":1172621466000},"page":"302-310","source":"Crossref","is-referenced-by-count":147,"title":["Cell surface markers for human T and B lymphocytes"],"prefix":"10.1002","volume":"4","author":[{"given":"G.","family":"Brown","sequence":"first","affiliation":[]},{"given":"M. F.","family":"Greaves","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2005,11,16]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"52","volume":"6","author":"Raff M. C.","year":"1971","journal-title":"Transplant. Rev."},{"key":"e_1_2_1_3_2","first-page":"3","volume":"15","author":"Katz D.","year":"1972","journal-title":"Advan. 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