{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T04:57:01Z","timestamp":1770699421591,"version":"3.49.0"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,11,16]],"date-time":"2005-11-16T00:00:00Z","timestamp":1132099200000},"content-version":"vor","delay-in-days":11246,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[1975,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The role of the H\u20102 gene complex in expression of cytotoxicity exerted by specific ectromelia\u2010immune thymus\u2010derived (T) cells against ectromelia\u2010infected target cells was examined. A repertoire of inbred mouse strains (some congenic) including the H\u20102 haplotypes k, d, b, s, q, the recombinant H\u20102<jats:sup>a<\/jats:sup> (k|d) and F<jats:sub>1<\/jats:sub> hybrids (k\/b and d\/b) were immunized with virus and their spleen cells tested 6 days later, at the peak of the primary response, against H\u20102<jats:sup>k<\/jats:sup>, H\u20102<jats:sup>d<\/jats:sup> and H\u20102<jats:sup>b<\/jats:sup> target cells. Significant specific cytotoxicity occurred only when the immune cell donors and the target cells shared all or part of the same H\u20102 gene complex. For example, H\u20102<jats:sup>a<\/jats:sup> (k|d) immune cells killed both H\u20102<jats:sup>k<\/jats:sup> and H\u20102<jats:sup>d<\/jats:sup> target cells. There wasno detectable effect of the non\u2010H\u20102 genetic background, H\u20102 public specificities, or the M\u2010locus Target cells infected with ectromelia virus exhibited quantitative or qualitative changes (or both) in expression of normal H\u20102 antigens as indicated by reduced susceptibility to killing by T cells activated against H\u20102 antigens in mixed lymphocyte culture. These data are consistent with the hypothesis that T cells in this system are responding to virus\u2010induced, specific changes in antigens on infected cells which are controlled by genes in the H\u20102 complex; these genes seem likely to be those coding for H\u20102 private specificities, or genes closely linked to them.<\/jats:p>","DOI":"10.1002\/eji.1830050210","type":"journal-article","created":{"date-parts":[[2007,2,28]],"date-time":"2007-02-28T01:36:48Z","timestamp":1172626608000},"page":"122-127","source":"Crossref","is-referenced-by-count":97,"title":["Cell\u2010mediated cytotoxicity against ectromelia virus\u2010infected target cells. III. Role of the H\u20102 gene complex"],"prefix":"10.1002","volume":"5","author":[{"given":"I. 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