{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,7]],"date-time":"2025-04-07T14:03:11Z","timestamp":1744034591595},"reference-count":13,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2005,11,16]],"date-time":"2005-11-16T00:00:00Z","timestamp":1132099200000},"content-version":"vor","delay-in-days":10973,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[1975,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The BAB\/14 (BALB\/c.C57BL\/Ka\u2010Ig\u20101<jats:sup>b<\/jats:sup>\/Hz) congenic mouse strain was found to respond to (4\u2010hydroxy\u20103\u2010nitrophenyl)acetyl (NP)\u2010chicken globulin immunization with nonheteroclitic anti\u2010NP antibodies as does the BALB\/c inbred partner strain. This is in contrast to the heteroclitic anti\u2010NP response of the C57BL\/Ka allotype donor strain and indicates that the allotype linked V<jats:sub>H<\/jats:sub>\u2010NP gene was inherited with the V<jats:sub>H<\/jats:sub>\u2010DEX gene from BALB\/c rather than with the allotype genes from C57BL\/Ka. This verifies the interpretation of BAB\/14 as an immunoglobulin gene recombinant.<\/jats:p><jats:p>Two recombinants between V<jats:sub>H<\/jats:sub>\u2010DEX and Ig\u20101 allotype genes have been found among 554 chromosomes tested yielding a recombination frequency of 0.4%. Analysis of the BAB\/14 recombinant showed that this crossover occurred between V<jats:sub>H<\/jats:sub> genes implying that V<jats:sub>H<\/jats:sub> genes and C<jats:sub>H<\/jats:sub> genes are not organized in separate clusters separated by a large spacer region but are contiguous. Analysis of the recombination frequencies indicates that the total number of V<jats:sub>H<\/jats:sub> genes must be at least 50.<\/jats:p>","DOI":"10.1002\/eji.1830051110","type":"journal-article","created":{"date-parts":[[2007,2,28]],"date-time":"2007-02-28T01:06:48Z","timestamp":1172624808000},"page":"778-781","source":"Crossref","is-referenced-by-count":27,"title":["Genetics of mouse antibodies. II. Recombination between V<sub>H<\/sub> genes and allotype"],"prefix":"10.1002","volume":"5","author":[{"given":"R.","family":"Riblet","sequence":"first","affiliation":[]},{"given":"M.","family":"Weigert","sequence":"additional","affiliation":[]},{"given":"O.","family":"M\u00e4kel\u00e4","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2005,11,16]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830051109"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.139.4.983"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.140.6.1498"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/250509a0"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-635501-7.50010-1"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.177.4044.178"},{"key":"e_1_2_1_8_2","first-page":"71","volume":"125","author":"Herzenberg L. 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