{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,12]],"date-time":"2023-11-12T16:14:36Z","timestamp":1699805676662},"reference-count":26,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2005,11,16]],"date-time":"2005-11-16T00:00:00Z","timestamp":1132099200000},"content-version":"vor","delay-in-days":10668,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[1976,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>H\u20102 alloantisera have been previously reported to contain antibodies against murine leukemia viral antigens, but the nature of the viral antigens on mouse cells which interact with these antibodies has not been established. We have found that H\u20102 alloantisera recognize components of molecular weight 70 000 \u2013 80 000 on mouse lymphocytes and leukemia cells. These components were also detected by a goat antiserum against the murine leukemia virus (MuLV) glycoprotein (gp70) and are therefore closely related to or identical with that viral protein.<\/jats:p><jats:p>Although most H\u20102 alloantisera detected gp70\u2010like molecules on lymphocytes and leukemia cells from a great variety of mouse strains, only one H\u20102 alloantiserum was found to interact with a gp70 component on cells from C57BL\/10 and C57BL\/6 mice. Animals such as C57BL\/10 mice that lacked the component reacting with most H\u20102 alloantisera showed increased serum levels of anti\u2010MuLV antibodies after injection of B10.A spleen cells having a gp70 component detectable by other H\u20102 alloantisera. In contrast, strains with cells reactive to antiviral antibodies in the H\u20102 alloantisera had low responses to MuLV antigens after a similar immunization procedure. Serum levels of anti\u2010MuLV antibodies in both groups of mice, however, were increased after injection of Freund's adjuvant. These observations suggest that anti\u2010MuLV antibodies in mouse alloantisera may arise from a response to viral antigens on the immunizing cells and general stimulation of the immune system.<\/jats:p>","DOI":"10.1002\/eji.1830060902","type":"journal-article","created":{"date-parts":[[2007,2,28]],"date-time":"2007-02-28T04:14:09Z","timestamp":1172636049000},"page":"603-607","source":"Crossref","is-referenced-by-count":14,"title":["Identification of the murine leukemia viral antigens detected on mouse cells by H\u20102 alloantisera"],"prefix":"10.1002","volume":"6","author":[{"given":"R. J.","family":"Milner","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Henning","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. M.","family":"Edelman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,16]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.71.9.3555"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-3527(08)60662-4"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.71.9.3682"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.141.1.172"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.141.1.198"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.142.2.518"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.139.6.1568"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.185.4154.869"},{"key":"e_1_2_1_10_2","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.4049\/jimmunol.115.5.1254","volume":"115","author":"Klein P. 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