{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T13:37:24Z","timestamp":1756993044746},"reference-count":26,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2005,11,16]],"date-time":"2005-11-16T00:00:00Z","timestamp":1132099200000},"content-version":"vor","delay-in-days":10668,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[1976,9]]},"abstract":"Abstract<\/jats:title>A newly discovered genetic marker in the kappa light chains of mouse immunoglobulins is described. This marker, designated K<\/jats:italic>\u2010PC8, is located in the L chains of those anti\u2010phosphorylcholine (PC) antibodies which show the same functional and idiotypic characteristics as a PC\u2010binding myeloma protein, HOPC 8 (H8). Analytical isoelectric focusing of these L chains revealed two phenotypes whose strain distribution pattern suggested a genetic association with genes that determine the T lymphocyte surface antigen(s) Ly\u20102\/Ly\u20103. In four strains, AKR\/J, C58\/J, RF\/J and PL\/J (AKR\u2010type, A) the H8\u2010like L chains have a slightly lower isoelectric point than those of C57L\/J and 12 other strains (C57L\u2010type, B). Breeding experiments showed that the K<\/jats:italic>\u2010PC8\u2010A phenotype is preferentially expressed. The most probable location of the marker is the variable region since other idiotypically related K<\/jats:italic>\u2010chains in CS7L\/J and AKR\/J do not show differences in their electrophoretic mobility.<\/jats:p>","DOI":"10.1002\/eji.1830060915","type":"journal-article","created":{"date-parts":[[2007,2,28]],"date-time":"2007-02-28T04:14:09Z","timestamp":1172636049000},"page":"666-668","source":"Crossref","is-referenced-by-count":31,"title":["Genetic marker in the variable region of kappa chains of mouse anti\u2010phosphorylcholine antibodies"],"prefix":"10.1002","volume":"6","author":[{"given":"J. L.","family":"Claflin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,16]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.135.3.579"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830020402"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.177.4044.178"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.139.4.983"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.140.3.673"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.140.6.1498"},{"key":"e_1_2_1_8_2","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1084\/jem.141.4.840","volume":"141","author":"Imanishi T.","year":"1975","journal-title":"J. Exp. 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