{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,12]],"date-time":"2023-11-12T13:12:52Z","timestamp":1699794772535},"reference-count":33,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2005,11,16]],"date-time":"2005-11-16T00:00:00Z","timestamp":1132099200000},"content-version":"vor","delay-in-days":10607,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[1976,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Incubation of spleen cells from mice having rejected a Moloney sarcoma virus (MSV)\u2010induced tumor with syngeneic irradiated lymphoma or sarcoma cells bearing MSV\u2010associated antigens in secondary mixed leukocyte\u2010tumor cell cultures (MLTC) resulted in the generation of highly active cytolytic T lymphocytes (CTL) specifically directed against syngeneic target cells bearing MSV\u2010associated antigens. When MSV\u2010immune spleen cells from C57BL\/6 (H\u20102<jats:sup>b<\/jats:sup>) and BALB\/c (H\u20102<jats:sup>d<\/jats:sup>) mice were compared with respect to their ability to generate CTL in syngeneic secondary MLTC, it was found that both lymphoid cell populations were equally able to mount an anamnestic CTL response to MSV\u2010associated antigens as assessed by a short\u2010term <jats:sup>51<\/jats:sup>Cr release assay. However, quantitative analysis of the activity of both CTL populations on either H\u20102<jats:sup>b<\/jats:sup> or H\u20102<jats:sup>d<\/jats:sup> tumor cells indicated that target cells sharing the same major histocompatibility complex (MHC) as the effector cells were lysed 10\u2010 to 100\u2010fold more efficiently than allogeneic target cells. As suggested by the results of inhibition experiments using mixtures of <jats:sup>51<\/jats:sup>Cr\u2010labeled and unlabeled target cells, preferential lysis of syngeneic versus allogeneic tumor cells might be related to the establishment of effective adhesions between the former and CTL.<\/jats:p><jats:p>Direct evidence for the role of MHC in determining the antigenic specificity of CTL directed against MSV\u2010associated antigens was provided by results obtained using MSV\u2010immune spleen cells from congenic resistant mice. Furthermore, studies of the response of F<jats:sub>1<\/jats:sub> (H\u20102<jats:sup>b\/d<\/jats:sup>) hybrid mice showed that stimulation of immune spleen cells with tumor cells from one parental strain or the other in secondary MLTC resulted in the generation of CTL capable of lysing tumor target cells of the same parental strain as the stimulating cells, but not of the other. The results thus suggested the presence of two sets of CTL precursor cells in F<jats:sub>1<\/jats:sub> MSV\u2010immune spleens, each set responding exclusively to tumor antigens associated with only one of the two parental phenotypes.<\/jats:p>","DOI":"10.1002\/eji.1830061114","type":"journal-article","created":{"date-parts":[[2007,2,28]],"date-time":"2007-02-28T02:36:43Z","timestamp":1172630203000},"page":"823-829","source":"Crossref","is-referenced-by-count":27,"title":["Antigenic specificity of the cytolytic T lymphocyte (CTL) response to murine sarcoma virus\u2010induced tumors. I. Preferential reactivity of <i>in vitro<\/i> generated secondary CTL with syngeneic tumor cells"],"prefix":"10.1002","volume":"6","author":[{"given":"F.","family":"Plats","sequence":"first","affiliation":[]},{"given":"J.\u2010C.","family":"Cerottini","sequence":"additional","affiliation":[]},{"given":"V.","family":"Jongeneel","sequence":"additional","affiliation":[]},{"given":"K. 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