{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,28]],"date-time":"2025-03-28T11:02:52Z","timestamp":1743159772723},"reference-count":26,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2005,11,22]],"date-time":"2005-11-22T00:00:00Z","timestamp":1132617600000},"content-version":"vor","delay-in-days":10340,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[1977,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A lymphocytic tumor, 38C\u201013, induced by the chemical carcinogen 7, 12\u2010di\u2010methylbenz(a)anthracene in C3H\/eB mice and adapted to tissue culture, produces 7\u20138 S IgM with \u201ccore\u201d carbohydrates (N\u2010acetylglucosamines, mannoses), but not \u201cbranch\u201d carbohydrates (neuraminic acids, fucoses, galactoses) attached to the \u03bc heavy, but not to the light chains. Turnover of the 7\u20138 S 38C\u201013 IgM is slow (half disappearance time = 10\u201315 h). The IgM is released from the cells as 7\u20138 S IgM. The ratio of IgM synthesis to the synthesis of all cellular glycoproteins is 0.005\u20130.01. After comparison of these data with data obtained with normal B lymphocytes before and after mitogenic stimulation, we conclude that 38C\u201013 tumor cells are transformed counterparts very near or within the population of small, mitogen\u2010sensitive, resting B lymphocytes.<\/jats:p>","DOI":"10.1002\/eji.1830070815","type":"journal-article","created":{"date-parts":[[2007,2,28]],"date-time":"2007-02-28T06:09:42Z","timestamp":1172642982000},"page":"574-579","source":"Crossref","is-referenced-by-count":26,"title":["An IgM\u2010producing tumor with biochemical characteristics of a small B lymphocyte"],"prefix":"10.1002","volume":"7","author":[{"given":"Y.","family":"Bergman","sequence":"first","affiliation":[]},{"given":"J.","family":"Haimovich","sequence":"additional","affiliation":[]},{"given":"F.","family":"Melchers","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2005,11,22]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.140.3.742"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830040305"},{"key":"e_1_2_1_4_2","first-page":"26","volume":"25","author":"Melchers F.","year":"1975","journal-title":"Transplant. Rev."},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830070702"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/241396a0"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.1040730305"},{"key":"e_1_2_1_8_2","first-page":"76","volume":"14","author":"Melchers F.","year":"1973","journal-title":"Transplant. Rev."},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.1975.tb02697.x"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj1150163"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj1250235"},{"key":"e_1_2_1_12_2","doi-asserted-by":"crossref","first-page":"446","DOI":"10.4049\/jimmunol.101.3.446","volume":"101","author":"Tyan M.L.","year":"1968","journal-title":"J. Immunol"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.135.6.1363"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4615-9017-0_3"},{"key":"e_1_2_1_15_2","unstructured":"Melchers F. Andersson J.andPhillips R.A. Cold Spring Harbor Symp. Quant. Biol.1977.41 in press."},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830050606"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/249361a0"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.138.3.557"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.142.5.1052"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830041113"},{"key":"e_1_2_1_21_2","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.4049\/jimmunol.115.5.1425","volume":"115","author":"H\u00e4mmerling U.","year":"1975","journal-title":"J. Immunol"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1101\/SQB.1977.041.01.028"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(77)90136-2"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi00719a028"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830040803"},{"key":"e_1_2_1_26_2","volume":"72","author":"Rosenberg N.","year":"1975","journal-title":"Proc Nat. Acad. Sci US"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(75)90005-7"}],"container-title":["European Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Feji.1830070815","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/eji.1830070815","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,2]],"date-time":"2023-11-02T18:42:32Z","timestamp":1698950552000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/eji.1830070815"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1977,8]]},"references-count":26,"journal-issue":{"issue":"8","published-print":{"date-parts":[[1977,8]]}},"alternative-id":["10.1002\/eji.1830070815"],"URL":"https:\/\/doi.org\/10.1002\/eji.1830070815","archive":["Portico"],"relation":{},"ISSN":["0014-2980","1521-4141"],"issn-type":[{"value":"0014-2980","type":"print"},{"value":"1521-4141","type":"electronic"}],"subject":[],"published":{"date-parts":[[1977,8]]}}}