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In contrast, mice injected intravenously with 1 x 10<jats:sup>9<\/jats:sup> SRBC were unresponsive to DTH induction through 1 x 10<jats:sup>8<\/jats:sup> SRBC injected into the footpad. This suppression of DTH was maintained for at least 6 weeks and was transferable by spleen, lymph node and thymus cells to normal syngeneic recipients. Bone marrow cells, on the other hand, did not contain the suppressor cells. The suppression of DTH was antigen\u2010specific in that DTH to chicken red blood cells and contact sensitivity to 2,4\u2010dinitrofluorobenzene was not affected. The suppressor cells were theta\u2010positive and Ig\u2010negative. They appeared in the spleen in optimum number 3\u20134 days after induction. The suppressor cells affected both the induction and manifestation of DTH. The presence of suppressor and effector cells for DTH inducible by different routes of antigenic presentation reflects the dynamic balance in the regulation of DTH.<\/jats:p>","DOI":"10.1002\/eji.1830071013","type":"journal-article","created":{"date-parts":[[2007,2,28]],"date-time":"2007-02-28T04:27:35Z","timestamp":1172636855000},"page":"714-718","source":"Crossref","is-referenced-by-count":70,"title":["Regulation of delayed\u2010type hypersensitivity I. T suppressor cells for delayed\u2010type hypersensitivity to sheep erythrocytes in mice"],"prefix":"10.1002","volume":"7","author":[{"given":"F.Y.","family":"Liew","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"170","volume":"26","author":"Gershon R.K.","year":"1975","journal-title":"Transplant. 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