{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T09:03:15Z","timestamp":1762160595824},"reference-count":33,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,12,5]],"date-time":"2005-12-05T00:00:00Z","timestamp":1133740800000},"content-version":"vor","delay-in-days":10169,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[1978,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Earlier work from two laboratories had shown that three mouse strains of allotype b produce a restricted response to hapten (4\u2010hydroxy\u20103\u2010nitrophenyl) acetyl (NP). These antibodies shared a peculiar heteroclitic fine specificity and exhibited a predictable although polyclonal isoelectric focusing (IEF) pattern in most of these mice. These characteristics were controlled by (an) Ig\u20101\u2010linked gene(s) (V<jats:sub>H<\/jats:sub>NF<jats:sup>b<\/jats:sup>). We report studies with a guinea pig anti\u2010idiotype serum which recognized the products of the V<jats:sub>H<\/jats:sub>NP<jats:sup>b<\/jats:sup> gene (idiotype NP\u2010b) but not other Ig. Binding of idiotype NP\u2010b was hapten\u2010inhibitable.<\/jats:p><jats:p>Idiotype NP\u2010b was the predominant (&gt; 85%) antibody population in the primary and secondary responses of C57BL\/6, and also in F<jats:sub>1<\/jats:sub> hybrid mice between C57BL\/6 and an idiotype\u2010negative strain. By preparative IEF, idiotype NP\u2010b was separated into fractions (IgG<jats:sub>1<\/jats:sub>(\u03bb) which had different affinities for the anti\u2010idiotype, and also slightly different binding affinities for analogues of NP.<\/jats:p><jats:p>Lambda<jats:sub>1<\/jats:sub> light chain seems to be required for the expression of the idiotype gene, but with the exception of the SJL strain, the light chain is not responsible for the observed genetic polymorphism. Besides, \u03bb is the predominant light chain in idiotype\u2010negative anti\u2010NP antibodies at least in strains BALB\/c, SM, DBA, A\/J and RF but not in strains CBA, AKR, NZB and SJL.<\/jats:p>","DOI":"10.1002\/eji.1830080207","type":"journal-article","created":{"date-parts":[[2007,2,28]],"date-time":"2007-02-28T09:36:45Z","timestamp":1172655405000},"page":"105-112","source":"Crossref","is-referenced-by-count":48,"title":["A mendelian idiotype is demonstrable in the heteroclitic anti\u2010NP antibodies of the mouse"],"prefix":"10.1002","volume":"8","author":[{"given":"K.","family":"Karjalainen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.","family":"M\u00e4kel\u00e4","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,5]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.177.4044.178"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.139.4.983"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.137.1.22"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.137.3.603"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.140.6.1498"},{"key":"e_1_2_1_7_2","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.4049\/jimmunol.115.5.1327","volume":"115","author":"McCarthy M. 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