{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T15:39:44Z","timestamp":1759333184784},"reference-count":28,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2005,12,6]],"date-time":"2005-12-06T00:00:00Z","timestamp":1133827200000},"content-version":"vor","delay-in-days":9989,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[1978,8]]},"abstract":"Abstract<\/jats:title>We have tested the proposition that induction of certain sets of B cell clones to produce antibody requires a signal from T helper cells that recognize idiotypic determinants expressed on Ig receptors of the relevant B cell clones. The approach is based on the analysis of T cell populations required to induce B cells to secrete anti\u2010arsonate antibodies that are marked by a cross\u2010reactive idiotype (CRId). CRId+<\/jats:sup> anti\u2010azophenyl arsonate (Ar) antibodies are produced in A\/J strain mice after immunization with Ar keyhole limpet hemocyanin and represent 20\u201370% of the total anti\u2010Ar antibody response.<\/jats:p>These studies indicate that antibody secretion by idiotype+<\/jats:sup> B memory cells requires two signals: one provided by \u201ccarrier\u201d\u2010specific Ly\u20101 cells, and a second delivered by idiotype\u2010specific Ly\u20101 cells. Both signals are required for optimal induction of idiotype+<\/jats:sup> B memory clones.<\/jats:p>","DOI":"10.1002\/eji.1830080812","type":"journal-article","created":{"date-parts":[[2007,2,28]],"date-time":"2007-02-28T10:06:39Z","timestamp":1172657199000},"page":"600-606","source":"Crossref","is-referenced-by-count":179,"title":["Idiotype\u2010specific T helper cells are required to induce idiotype\u2010positive B memory cells to secrete antibody"],"prefix":"10.1002","volume":"8","author":[{"given":"R.","family":"Woodland","sequence":"first","affiliation":[]},{"given":"H.","family":"Cantor","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2005,12,6]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830010104"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.129.6.1131"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.137.6.1405"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.142.1.197"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.143.4.861"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830051002"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830040413"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.142.5.1121"},{"key":"e_1_2_1_10_2","first-page":"373","volume":"125","author":"Jerne N. 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