{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T15:27:26Z","timestamp":1759332446338},"reference-count":16,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,11,16]],"date-time":"2005-11-16T00:00:00Z","timestamp":1132099200000},"content-version":"vor","delay-in-days":9816,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[1979,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Little use has been made previously of the observation that interferon is generated in the murine mixed lymphocyte reaction (MLR). We have found high levels of interferon in the supernatants of MLR between spleen cells of mice of different H\u20102 type after one to two days of culture. Interferon production was also seen in strain combinations that differed only in the K or D region of the H\u20102 complex. There was no production of interferon in strain combinations differing in the M locus or in the I region of the H\u20102 complex. The latter combinations are known not to induce cytotoxic effector cells. Thus, there seems to be a dichotomy in allogeneic determinants between those of the I region and of the M locus inducing primarily lymphoprolifertion, and those of H\u20102K and H\u20102D inducing cytotoxic activity and interferon production.<\/jats:p>","DOI":"10.1002\/eji.1830090121","type":"journal-article","created":{"date-parts":[[2007,2,28]],"date-time":"2007-02-28T10:11:04Z","timestamp":1172657464000},"page":"97-99","source":"Crossref","is-referenced-by-count":37,"title":["Interferon production in the murine mixed lymphocyte culture. I. Interferon production caused by differences in the H\u20102 K and H\u20102 D region but not by differences in the I region or the M locus"],"prefix":"10.1002","volume":"9","author":[{"given":"Holger","family":"Kirchner","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rainer","family":"Zawatzky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Volker","family":"Schirrmacher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,16]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.123.4.665"},{"key":"e_1_2_1_3_2","first-page":"62","volume":"15","author":"Festenstein H.","year":"1973","journal-title":"Transplant. Rev."},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01570493"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.137.5.1303"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.142.6.1477"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830030711"},{"key":"e_1_2_1_8_2","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1128\/iai.3.1.164-166.1971","volume":"3","author":"Gifford G. E.","year":"1971","journal-title":"Infect. Immun."},{"key":"e_1_2_1_9_2","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1128\/iai.17.2.282-285.1977","volume":"17","author":"Virelizier J. L.","year":"1977","journal-title":"Infect. Immun."},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0008-8749(77)90262-3"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0008-8749(78)90042-4"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/237120a0"},{"key":"e_1_2_1_13_2","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.4049\/jimmunol.112.4.1589","volume":"112","author":"Stobo J.","year":"1974","journal-title":"J. Immunol."},{"key":"e_1_2_1_14_2","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1128\/iai.15.1.78-83.1977","volume":"15","author":"Maehara N.","year":"1977","journal-title":"Infect. Immun."},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830071014"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.118.2.721"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/247205a0"}],"container-title":["European Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Feji.1830090121","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/eji.1830090121","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,7]],"date-time":"2023-10-07T07:18:21Z","timestamp":1696663101000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/eji.1830090121"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1979,1]]},"references-count":16,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1979,1]]}},"alternative-id":["10.1002\/eji.1830090121"],"URL":"https:\/\/doi.org\/10.1002\/eji.1830090121","archive":["Portico"],"relation":{},"ISSN":["0014-2980","1521-4141"],"issn-type":[{"value":"0014-2980","type":"print"},{"value":"1521-4141","type":"electronic"}],"subject":[],"published":{"date-parts":[[1979,1]]}}}