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BBM.1 antibody was fully inhibited by soluble \u03b2\u2010microglobulin and purified HLA\u2010A, B antigens and reacted with humanmouse somatic cell hybrids only if they had chromosome 15 and expressed human \u03b2\u2010microglobulin. It was cytotoxic in complement\u2010dependent lysis and of the IgG class. BBM.1 and a monoclonal anti\u2010HLA\u2010A, B, C glycoprotein antibody, W6\/32 (Barnstable, C. J. et al., <jats:italic>Cell<\/jats:italic> 1978. <jats:italic>14<\/jats:italic>: 9.), were used to quantitate relative amounts of \u03b2<jats:sub>2<\/jats:sub> \u2010microglobulin and HLA\u2010A, B, C glycoproteins on different human cell types. Thymocytes and the Molt 4 cell line showed a considerable excess of \u03b2<jats:sub>2<\/jats:sub>\u2010microglobulin over HLA\u2010A, B, C glycoproteins, as measured by W6\/32 reactivity. B cell lines, peripheral blood lymphocytes, fibroblasts, a HeLa cell derivative, and HSB 2, another T cell line, had equal amounts. Immunological cross\u2010reactions between HLA\u2010A, B, C antigens and \u03b2\u2010microgloglobulin and their homologues in other species were detected with the BBM.1 and W6\/32 antibodies. The W6\/32 antigenic determinant appears to be more highly conserved than that recognized by the BBM.1 antibody.<\/jats:p>","DOI":"10.1002\/eji.1830090709","type":"journal-article","created":{"date-parts":[[2007,2,28]],"date-time":"2007-02-28T11:11:56Z","timestamp":1172661116000},"page":"536-545","source":"Crossref","is-referenced-by-count":223,"title":["Characterization of a monoclonal anti\u2010\u03b2<sub>2<\/sub>\u2010microglobulin antibody and its use in the genetic and biochemical analysis of major histocompatibility antigens"],"prefix":"10.1002","volume":"9","author":[{"given":"Frances M.","family":"Brodsky","sequence":"first","affiliation":[]},{"given":"Walter F.","family":"Bodmer","sequence":"additional","affiliation":[]},{"given":"Peter","family":"Parham","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2005,11,16]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(78)90296-9"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/256495a0"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/271249a0"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/273666a0"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/276397a0"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830081203"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.71.3.962"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01542686"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-401660-6.50043-6"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.70.10.2863"},{"key":"e_1_2_1_12_2","first-page":"126","volume":"21","author":"Strominger J. 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