{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,1,13]],"date-time":"2024-01-13T03:20:27Z","timestamp":1705116027653},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,11,16]],"date-time":"2005-11-16T00:00:00Z","timestamp":1132099200000},"content-version":"vor","delay-in-days":9420,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[1980,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Anti\u2010NP [(4\u2010hydroxy\u20103\u2010nitro\u2010phenyl)acetyl)] antibodies from the primary response of BALB\/c mice contain a major idiotype NP\u2010a that is controlled by an allotype\u2010linked gene V<jats:sub>H<\/jats:sub>NP<jats:sup>a<\/jats:sup>. A new strain distribution pattern for a V<jats:sub>H<\/jats:sub> marker was discovered: strains BALB\/c, RF, DBA, RIII and SM were positive, and strains C57BL\/6, SJL, CBA, A\/J, CE, AKR and NZB were negative for the idiotype NP\u2010a.<\/jats:p><jats:p>NP\u2010a idiotype shared many characteristics with previously described idiotype NP\u2010b and, therefore, allelism was suggested between them. Both idiotypes have \u03b3 light chains, both seem to be conservative in evolution, both are predominant early in the antibody response. Later during the response, antibodies become increasingly idiotype\u2010negative while at the same time, homogeneous isoelectric focusing patterns become very heterogeneous. The study of V<jats:sub>H<\/jats:sub> recombinant strains supported the concept of allelism because in every case studied, the idiotypes were mutually exclusive. (C57BL\/6 \u00d7 BALB\/c)F<jats:sub>1<\/jats:sub> mice expressed idiotypes NP\u2010a and NP\u2010b regularly and in approximately equal amounts.<\/jats:p>","DOI":"10.1002\/eji.1830100212","type":"journal-article","created":{"date-parts":[[2007,2,28]],"date-time":"2007-02-28T12:37:22Z","timestamp":1172666242000},"page":"132-139","source":"Crossref","is-referenced-by-count":23,"title":["Two major idiotypes in mouse anti\u2010(4\u2010hydroxy\u20103\u2010nitrophenyl)acetyl (NP) antibodies are controlled by \u201callelic\u201d genes"],"prefix":"10.1002","volume":"10","author":[{"given":"Klaus","family":"Karjalainen","sequence":"first","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2005,11,16]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01892405"},{"key":"e_1_2_1_3_2","volume-title":"B Lymphocyies in the Immune Response","author":"M\u00e4kel\u00e4 O.","year":"1978"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.75.9.4494"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.140.5.1432"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.74.10.4600"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830060915"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830080207"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830070813"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.140.6.1498"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1101\/SQB.1977.041.01.084"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01572284"},{"key":"e_1_2_1_13_2","unstructured":"M\u00e4kel\u00e4 O. Karjalainen K.andPotter M. Ann. Immunol. (Paris)1979 in press."},{"key":"e_1_2_1_14_2","first-page":"465","volume":"10","author":"Brownstone A.","year":"1966","journal-title":"Immunology"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0019-2791(72)90084-5"},{"key":"e_1_2_1_16_2","first-page":"81","volume":"10","author":"M\u00e4kel\u00e4 O.","year":"1966","journal-title":"Immunology"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-197103000-00013"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-143-37380"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj0890114"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.148.6.1644"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.116.3.676"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/0161-5890(78)90070-6"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830080605"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.144.5.1164"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1101\/SQB.1977.041.01.093"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.1978.tb00430.x"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.148.5.1122"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.75.3.1495"},{"key":"e_1_2_1_29_2","doi-asserted-by":"crossref","first-page":"2105","DOI":"10.4049\/jimmunol.117.6.2105","volume":"117","author":"Lieberman R.","year":"1976","journal-title":"J. Immunol."},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/250509a0"},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.1086\/281181"},{"key":"e_1_2_1_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0340-904X(78)80022-0"},{"key":"e_1_2_1_33_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.147.5.1517"}],"container-title":["European Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Feji.1830100212","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/eji.1830100212","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,2]],"date-time":"2023-11-02T13:37:58Z","timestamp":1698932278000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/eji.1830100212"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1980,2]]},"references-count":32,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1980,2]]}},"alternative-id":["10.1002\/eji.1830100212"],"URL":"https:\/\/doi.org\/10.1002\/eji.1830100212","archive":["Portico"],"relation":{},"ISSN":["0014-2980","1521-4141"],"issn-type":[{"value":"0014-2980","type":"print"},{"value":"1521-4141","type":"electronic"}],"subject":[],"published":{"date-parts":[[1980,2]]}}}