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The cytotoxic killing of virus\u2010 infected cells was differentially inhibited by three monoclonal antibodies to H\u20102<jats:sup>k<\/jats:sup>. Synergistic inhibition of cytotoxic activity was obtained with monoclonal antibodies to H\u20102 and to some antigenic determinants on the hemagglutinin melecule of A\/USSR but not with others. Since target cells infected with other subtypes of influenza A viruses were not inhibited by any of the monoclonal antibodies to AIUSSR hemagglutinin, it is suggested that the sites recognized by the cross\u2010reactive cytotoxic T cells were satirically inhibited by the anti\u2010A\/USSR monoclonal antibodies. The results suggest that at least one of the target antigens recognized by the cross\u2010reactive population of cytotoxic T cells is located on the hemagglutinin molecule. The present observations are in agreement with cytotoxic T cell recognition of closely situated viral and H\u2010 2 determinants.<\/jats:p>","DOI":"10.1002\/eji.1830100215","type":"journal-article","created":{"date-parts":[[2007,2,28]],"date-time":"2007-02-28T12:37:22Z","timestamp":1172666242000},"page":"151-156","source":"Crossref","is-referenced-by-count":26,"title":["Monoclonal antibodies to hemagglutinin and to H\u20102 inhibit the cross\u2010reactive cytotoxic T cell populations induced by influenza"],"prefix":"10.1002","volume":"10","author":[{"given":"Brigitte A.","family":"Askonas","sequence":"first","affiliation":[]},{"given":"Robert G.","family":"Webster","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2005,11,16]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"89","volume":"29","author":"Doherty P. C.","year":"1976","journal-title":"Transplant. 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