{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T15:59:06Z","timestamp":1770739146060,"version":"3.49.0"},"reference-count":25,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2005,11,16]],"date-time":"2005-11-16T00:00:00Z","timestamp":1132099200000},"content-version":"vor","delay-in-days":9269,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[1980,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Evidence is presented that the organ specificity of lymphocyte migration is determined by selective interaction of lymphocytes with specialized endothelial cells. Mouse Peyer's patch and lymph node lymphocytes bind preferentially to high endothelial venules (HEV) in frozen sections of Peyer's patches and peripheral nodes, respectively, and this <jats:italic>in vitro<\/jats:italic> binding preference accurately predicts their differential segregation <jats:italic>in vivo<\/jats:italic> 30 min after i.v. injection. Both <jats:italic>in vivo<\/jats:italic> and <jats:italic>in vitro<\/jats:italic>, about 1.4 times as many Peyer's patch as lymph node lymphocytes bind HEV in Peyer's patches, and, conversely, twice as many lymph node cells interact with HEV in nonmesenteric lymph nodes. Even greater specificity is shown by certain homogeneous lymphocyte populations, <jats:italic>i.e.<\/jats:italic> thymic lymphomas. Some lymphomas bind with remarkable selectivity to HEV in Peyer's patches, and others interact almost exclusively with those in lymph nodes indicating that the mechanisms mediating selective recognition of HEV are capable of nearly absolute discrimination. Mesenteric node HEV are unique in that they allow both Peyer's patch\u2010 and lymph node\u2010specific cells to bind. It is proposed that lymphocyte surface receptors specific for organ\u2010restricted endothelial cell determinants mediate the antigen\u2010independent organ specificity of lymphocyte migration. According to this model, there are at least 2 sets of complementary lymphocyte and endothelial cell receptors, one mediating lymphocyte\u2010HEV adherence in Peyer's patches, the other in lymph nodes.<\/jats:p>","DOI":"10.1002\/eji.1830100713","type":"journal-article","created":{"date-parts":[[2007,2,28]],"date-time":"2007-02-28T13:20:47Z","timestamp":1172668847000},"page":"556-561","source":"Crossref","is-referenced-by-count":235,"title":["Organ specificity of lymphocyte migration: mediation by highly selective lymphocyte interaction with organ\u2010specific determinants on high endothelial venules"],"prefix":"10.1002","volume":"10","author":[{"given":"Eugene C.","family":"Butcher","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roland G.","family":"Scollay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irving L.","family":"Weissman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,16]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.130.6.1427"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830040610"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.148.6.1661"},{"key":"e_1_2_1_5_2","first-page":"203","volume":"16","author":"Smith M. E.","year":"1980","journal-title":"Monogr. Allergy"},{"key":"e_1_2_1_6_2","doi-asserted-by":"crossref","first-page":"1892","DOI":"10.4049\/jimmunol.122.5.1892","volume":"122","author":"McDermott M. R.","year":"1979","journal-title":"J. Immunol."},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830070108"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/260528a0"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.145.2.420"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-197209000-00009"},{"key":"e_1_2_1_11_2","first-page":"571","volume":"26","author":"Parrott D. M. V.","year":"1974","journal-title":"Immunology"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.148.5.1146"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.1964.0001"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.144.3.828"},{"key":"e_1_2_1_15_2","doi-asserted-by":"crossref","first-page":"772","DOI":"10.4049\/jimmunol.119.2.772","volume":"119","author":"Stamper H. B.","year":"1977","journal-title":"J. Immunol."},{"key":"e_1_2_1_16_2","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.4049\/jimmunol.119.5.1603","volume":"119","author":"Woodruff J. J.","year":"1977","journal-title":"J. Immunol."},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4615-9101-6_11"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.123.5.1996"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/280496a0"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.130.3372.387"},{"key":"e_1_2_1_21_2","first-page":"319","volume-title":"Linear Statistical Inference and Its Applications","author":"Rao C. R.","year":"1965"},{"key":"e_1_2_1_22_2","volume-title":"Handbook of Experimental Immunology","author":"Ford W. L.","year":"1978"},{"key":"e_1_2_1_23_2","first-page":"509","volume":"29","author":"Rannie G. H.","year":"1977","journal-title":"Clin. Exp. Immunol."},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-157-39991"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/270731a0"},{"key":"e_1_2_1_26_2","doi-asserted-by":"crossref","unstructured":"Cahill R. N. P. Heron I. Poskitt D. C.andTrnka Z. inBlood Cells and Vessel Walls: Functional Interactions Ciba Foundation Symposium No. 71 Excerpta Medica Amsterdam1980 p.145.","DOI":"10.1002\/9780470720547.ch9"}],"container-title":["European Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Feji.1830100713","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/eji.1830100713","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,19]],"date-time":"2023-10-19T15:07:34Z","timestamp":1697728054000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/eji.1830100713"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1980,7]]},"references-count":25,"journal-issue":{"issue":"7","published-print":{"date-parts":[[1980,7]]}},"alternative-id":["10.1002\/eji.1830100713"],"URL":"https:\/\/doi.org\/10.1002\/eji.1830100713","archive":["Portico"],"relation":{},"ISSN":["0014-2980","1521-4141"],"issn-type":[{"value":"0014-2980","type":"print"},{"value":"1521-4141","type":"electronic"}],"subject":[],"published":{"date-parts":[[1980,7]]}}}