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General cytotoxic effects of the drug on proliferating T cells became apparent at concentrations of 500\u20131000 ng\/ml, while selective effects were observed at concentrations of 10\u2013100 ng\/ml. The selective effects included a blockade of interleukin 2 release from activated T helper cells on the one hand and inhibition of interleukin 1 release from splenic adherent cells on the other. While cyclosporin A did not interfere with the intracellular events required for the activation and subsequent clonal expansion of alloreactive T cells, the lack of interleukin 1 and interleukin 2 induced by cyclosporin A results in an inability of T responder cells to mount cytotoxic allograft responses <jats:italic>in vitro<\/jats:italic>.<\/jats:p>","DOI":"10.1002\/eji.1830110812","type":"journal-article","created":{"date-parts":[[2007,2,28]],"date-time":"2007-02-28T14:10:16Z","timestamp":1172671816000},"page":"657-661","source":"Crossref","is-referenced-by-count":458,"title":["Cyclosporin A mediates immunosuppression of primary cytotoxic T cell responses by impairing the release of interleukin 1 and interleukin 2"],"prefix":"10.1002","volume":"11","author":[{"given":"Donald","family":"Bunjes","sequence":"first","affiliation":[]},{"given":"Conny","family":"Hardt","sequence":"additional","affiliation":[]},{"given":"Martin","family":"R\u00f6llinghoff","sequence":"additional","affiliation":[]},{"given":"Hermann","family":"Wagner","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2005,11,16]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"1017","volume":"32","author":"Borel J. 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