{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T02:59:42Z","timestamp":1770433182658,"version":"3.49.0"},"reference-count":36,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2005,11,16]],"date-time":"2005-11-16T00:00:00Z","timestamp":1132099200000},"content-version":"vor","delay-in-days":9085,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[1981,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The polymorphic nature of the immunoglobulin V<jats:sub>H<\/jats:sub> genes was investigated by Southern blot analysis of liver DNA of sixteen different mouse strains and hybridization with V<jats:sub>H<\/jats:sub> probes. Differences in restriction enzyme pattern (REP) were observed and six different patterns of restriction fragments were found for the sixteen strains analyzed. No equivalent polymorphism was observed in another multigene family, the actins. The six patterns correlate with immunoglobin constant region allotypes (Igh\u20101). Experiments with Igh\u20101\u2010congenic strains suggest that the V<jats:sub>H<\/jats:sub> REP is linked to immunoglobulin constant region haplotype. Mouse strains which share inherited idiotypes also share identical V<jats:sub>H<\/jats:sub> restriction pattern. This provides a structural basis for the genetic linkage between idiotypes and allotypes. It also indicates that different strains carry different VH gene repertoires, which may be the basis for the expression of different inherited idiotypes in various strains. We propose that a V<jats:sub>H<\/jats:sub> group is a set of linked genes that are coinherited as a cluster with the constant region genes and that V<jats:sub>H<\/jats:sub> and C<jats:sub>H<\/jats:sub> can be regarded as an extended haplotype.<\/jats:p>","DOI":"10.1002\/eji.1830111213","type":"journal-article","created":{"date-parts":[[2007,2,28]],"date-time":"2007-02-28T13:36:31Z","timestamp":1172669791000},"page":"1017-1020","source":"Crossref","is-referenced-by-count":16,"title":["Polymorphism of germ\u2010line immunoglobulin V<sub>H<\/sub> genes correlates with allotype and idiotype markers"],"prefix":"10.1002","volume":"11","author":[{"given":"Yinon","family":"Ben\u2010Neriah","sequence":"first","affiliation":[]},{"given":"Justus B.","family":"Cohen","sequence":"additional","affiliation":[]},{"given":"Gideon","family":"Rechavi","sequence":"additional","affiliation":[]},{"given":"Rina","family":"Zakut","sequence":"additional","affiliation":[]},{"given":"David","family":"Givol","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2005,11,16]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.75.3.1485"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/280370a0"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.76.2.857"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/290562a0"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.99815"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/284238a0"},{"key":"e_1_2_1_8_2","volume-title":"Handbook of Experimental Immunology","author":"Herzenberg L. 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