{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T15:25:57Z","timestamp":1759332357140},"reference-count":39,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,12,5]],"date-time":"2005-12-05T00:00:00Z","timestamp":1133740800000},"content-version":"vor","delay-in-days":8739,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[1982,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The primary antibody response in BALB\/c mice to the T\u2010independent bacterial antigen dextran B1355S [\u03b1(l \u2192 3)dextran] (Dex) was studied by means of isoelectric focusing, hemagglutination and immunodiffusion techniques. In response to a single immunization with 10 kg Dex all mice produce specific IgM antibodies. In addition, about 30% of conventionally raised BALB\/c and BALB\/c nu\/+ mice, but 95% of germ\u2010free (GF)\u2010raised normal BALB\/c and 100% of athymic BALB\/c nu\/nu mice produce specific IgG class anti\u2010Dex antibodies. These antibodies include all IgG subclasses, carry predominantly the \u03bb light chain and the cross\u2010reactive J558 idiotype and are specific for the \u03b1(1 \u2192 3)glucosidic linkage.<\/jats:p><jats:p>As compared to athymic and GF\u2010raised mice, conventionally raised mice exhibit only a weak IgG response. The pronounced IgG production of GF\u2010raised mice was not altered when adult mice were removed from their GF environment and housed under conventional conditions for several weeks prior to immunization with Dex. Reconstitution with isolated splenic T cells from conventionally raised, unprimed BALB\/c mice reduces the remarkable capacity of BALB\/c nu\/nu mice to produce IgG anti\u2010Dex antibodies.<\/jats:p><jats:p>These findings suggest that the reduced capacity of conventionally raised BALB\/c mice to mount an IgG response to the T\u2010independent antigen Dex is due to a T cell\u2010mediated suppressive mechanism which is neonatally induced by contact with environmental, <jats:italic>i. e.<\/jats:italic> bacterial, antigens.<\/jats:p>","DOI":"10.1002\/eji.1830120205","type":"journal-article","created":{"date-parts":[[2007,2,28]],"date-time":"2007-02-28T15:02:49Z","timestamp":1172674969000},"page":"120-125","source":"Crossref","is-referenced-by-count":28,"title":["Immune response against the T\u2010independent antigen \u03b1(1\u21923)dextran. I. 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