{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T18:46:40Z","timestamp":1774378000497,"version":"3.50.1"},"reference-count":33,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,12,9]],"date-time":"2005-12-09T00:00:00Z","timestamp":1134086400000},"content-version":"vor","delay-in-days":8743,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[1982,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A rat Ia (RT\u20101B) antigen (called Ia\u2010A) equivalent to the mouse I\u2010A product has been defined with mouse monoclonal antibodies (W. R. McMaster and A. F. Williams, <jats:italic>Eur. J. Immunol.<\/jats:italic> 1979. <jats:italic>9<\/jats:italic>: 426). To identify other Ia antigens mouse monoclonal antibodies were raised against rat spleen glycoproteins depleted of the Ia\u2010A antigen. An IgG antibody (called MRC OX 17) was obtained and used to purify a molecule which had a similar structure to the Ia\u2010A antigen and reacted with anti\u2010Ia alloantibodies. There was no cross\u2010reaction between the two Ia glycoproteins in assays with mouse monoclonal antibodies, alloantibodies or rabbit antibodies. In one alloantiserum almost all the detectable anti\u2010Ia antibodies reacted with a mixture of the two Ia glycoproteins. The MRC OX 17 antibody did not bind to mouse cells, but rabbit antibodies to the pure rat glycoprotein cross\u2010reacted and recognized determinants mapping to the mouse I\u2010E region. In the thymus the rat Ia\u2010E antigen was on cortical epithelial and medullary reticular cells.<\/jats:p><jats:p>An IgG monoclonal antibody (MRC OX 18) to isotypic determinants of rat histocompatibility RT\u20101A antigens was also produced and used to analyze these antigens on thymus cells. The heavily labeled thymocytes were those with characteristics of mature T lymphocytes. Cortical epithelial cells and medullary dendritic\u2010like cells were also RT\u20101A positive.<\/jats:p>","DOI":"10.1002\/eji.1830120313","type":"journal-article","created":{"date-parts":[[2007,2,28]],"date-time":"2007-02-28T14:57:45Z","timestamp":1172674665000},"page":"237-243","source":"Crossref","is-referenced-by-count":255,"title":["Mouse monoclonal antibodies against rat major histocompatibility antigens. Two Ia antigens and expression of Ia and class I antigens in rat thymus"],"prefix":"10.1002","volume":"12","author":[{"given":"Tetsuo","family":"Fukumoto","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"Robert McMaster","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan F.","family":"Williams","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,9]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"236","volume":"30","author":"Cullen S. E.","year":"1976","journal-title":"Transplant. 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