{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,1,13]],"date-time":"2024-01-13T03:21:50Z","timestamp":1705116110848},"reference-count":33,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2005,12,9]],"date-time":"2005-12-09T00:00:00Z","timestamp":1134086400000},"content-version":"vor","delay-in-days":8743,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[1982,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A comparative antigenic analysis was carried out to determine whether cross\u2010reactivity exists between the major idiotypic responses to (4\u2010hydroxy\u20103\u2010nitrophenyl)acetyl (NP) in BALB\/c and C57BL\/6 mice. Extensive cross\u2010reactivity exists between the NP<jats:sup>a<\/jats:sup> (BALB\/c) and NP<jats:sup>b<\/jats:sup> (C57BL\/6) allotype\u2010linked idiotypic responses to NP. The cross\u2010reactive determinants of the NP<jats:sup>b<\/jats:sup> idiotype are confined to one particular group of NP<jats:sup>b<\/jats:sup>\u2010positive monoclonal antibodies. The extent of cross\u2010reactivity between this group of C57BL\/6 antibodies and idiotype\u2010positive monoclonal antibodies of BALB\/c is so great that they cannot be readily distinguished as NP<jats:sup>b<\/jats:sup>\u2010 or NP<jats:sup>a<\/jats:sup>\u2010positive antibodies with polyclonal anti\u2010idiotypic reagents. That this cross\u2010reactivity is not unique to monoclonal antibodies was confirmed by the demonstration of these cross\u2010reactive determinants in the immune sera of individual BALB\/c and C57BL\/6 mice. Additionally, evidence was obtained from these experiments and from earlier ones from this laboratory which suggests that the BALB\/c idiotypic response to NP\u2010protein conjugate is more homogeneous than the C57BL\/6 idiotypic responses.<\/jats:p>","DOI":"10.1002\/eji.1830121108","type":"journal-article","created":{"date-parts":[[2007,2,28]],"date-time":"2007-02-28T14:36:58Z","timestamp":1172673418000},"page":"935-942","source":"Crossref","is-referenced-by-count":12,"title":["Cross\u2010reactivity of the NP<sup>a<\/sup> and NP<sup>b<\/sup> idiotypic responses of BALB\/c and C57BL\/6 mice to (4\u2010hydroxy\u20103\u2010nitrophenyl)acetyl (NP)"],"prefix":"10.1002","volume":"12","author":[{"given":"Mary E.","family":"White\u2010Scharf","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thereza","family":"Imanishi\u2010Kari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,9]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.177.4044.178"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.137.1.22"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.137.3.603"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.139.4.983"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.140.6.1498"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01572284"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.77.7.4270"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.77.2.1120"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.152.3.703"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/283035a0"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830070813"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830080207"},{"key":"e_1_2_1_14_2","first-page":"20","volume":"81","author":"Imanishi\u2010Kari T.","year":"1978","journal-title":"Curr. 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