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A gene or genes linked to the heavy chain constant region locus is required for the production of this idiotype. The expressed V<jats:sub>H<\/jats:sub> gene from a hybridoma cell line which expresses the Id<jats:sup>CR<\/jats:sup> has been cloned. DNA hybridization studies utilizing the V<jats:sub>H<\/jats:sub> gene have revealed that there are many related genes in both idiotype\u2010producing and idiotype\u2010nonproducing strains of mice. However, under stringent hybridization conditions, only a single band of 6.4 kb is present in Eco R1\u2010digested A strain DNA. Strains of mice which are phenotypically idiotype\u2010negative either lack this band completely or possess a much weaker one at this position. Utilizing DNA from Igh recombinant strains of mice, it has been shown that the V<jats:sub>H<\/jats:sub> locus controlling idiotype expression contains the structural gene information for the idiotype\u2010positive heavy chains. It has also been shown that DNA at this locus appears to be sufficient for the production of the cross\u2010reactive idiotype. Utilizing a DNA probe derived from regions flanking the structural gene has confirmed the relatedness of V genes in a variety of mouse strains and revealed a significant degree of polymorphism at the Igh locus.<\/jats:p>","DOI":"10.1002\/eji.1830121208","type":"journal-article","created":{"date-parts":[[2007,2,28]],"date-time":"2007-02-28T15:14:14Z","timestamp":1172675654000},"page":"1023-1032","source":"Crossref","is-referenced-by-count":54,"title":["The genetic basis of antibody production: The dominant anti\u2010arsonate idiotype response of the strain a mouse"],"prefix":"10.1002","volume":"12","author":[{"given":"Miriam","family":"Siekevitz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malcolm L.","family":"Gefter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Brodeur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roy","family":"Riblet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ann","family":"Marshak\u2010Rothstein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,9]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01892405"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.1977.tb00369.x"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.145.4.876"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830080812"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.150.6.1399"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.135.3.579"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.145.3.540"},{"key":"e_1_2_1_9_2","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.4049\/jimmunol.125.5.1987","volume":"125","author":"Marshak\u2010Rothstein A.","year":"1980","journal-title":"J Immunol."},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.137.1.22"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.74.10.4600"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.77.2.1120"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0161-5890(79)90045-2"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830110709"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1973.tb02881.x"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/277627a0"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.322278"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.74.8.3518"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.75.9.4242"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/0378-1119(77)90049-X"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.322279"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.847462"},{"key":"e_1_2_1_23_2","volume-title":"Manual in Advanced Bacterial Genetics","author":"Berman M. 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