{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T15:24:32Z","timestamp":1759332272005},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,11,16]],"date-time":"2005-11-16T00:00:00Z","timestamp":1132099200000},"content-version":"vor","delay-in-days":8355,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[1983,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The purpose of this work was to study the interrelationship of proliferation and secretion of plasminogen activator (PA) and interferon (IFN) by murine macrophages. For induction of macrophage proliferation and secretion of PA, concanavalin A (Con A) was used. Secretion of IFN was induced by polyinosinic polycytidylic acid complex. The glucocorticoid dexamethasone acetate (DA) (10<jats:sup>\u22126<\/jats:sup> \u2212 10<jats:sup>9<\/jats:sup> <jats:sc>M<\/jats:sc>) inhibited Con A\u2010stimulated secretion of PA and synthesis of DNA as evaluated by incorporation of [<jats:sup>3<\/jats:sup>H]thymidine. DA did not inhibit IFN induction. Preincubating macrophages with DA for 45 h reduced basal proliferation and secretion of PA but did not reduce responsiveness to Con A. Also retinoic acid, a modulator of carcinogenesis was used in inhibition studies because of its known antagonistic effects on lymphocyte mitogenesis. In macrophages a biphasic effect of retinoic acid (1 \u00d7 10<jats:sup>\u22125<\/jats:sup> \u2212 5 \u00d7 10<jats:sup>\u22125<\/jats:sup><jats:sc>M<\/jats:sc>) was found: (a) inhibition of DNA synthesis and secretion of PA during the first 45 h of incubation, and (b) enhancement of DNA synthesis (but not PA secretion) after 72 h. Secretion of IFN was not affected. It is suggested that secretion of PA but not IFN is linked to cell cycle traverse of macrophages.<\/jats:p>","DOI":"10.1002\/eji.1830130210","type":"journal-article","created":{"date-parts":[[2007,2,28]],"date-time":"2007-02-28T20:01:12Z","timestamp":1172692872000},"page":"143-147","source":"Crossref","is-referenced-by-count":14,"title":["Regulation of plasminogen activator secretion, interferon induction and proliferation in murine macrophages"],"prefix":"10.1002","volume":"13","author":[{"given":"Christine","family":"Neumann","sequence":"first","affiliation":[]},{"given":"Clemens","family":"Sorg","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2005,11,16]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"189","volume-title":"Mononuclear Phagocytes in Immunity, Infection and Pathology","author":"Goud Th. J. L. 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