{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T14:29:38Z","timestamp":1698157778354},"reference-count":23,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2005,11,16]],"date-time":"2005-11-16T00:00:00Z","timestamp":1132099200000},"content-version":"vor","delay-in-days":7990,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[1984,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The E receptor (binds sheep erythrocytes) is found on virtually all human T cells. Here we show that a monoclonal antibody 9.6, which recognizes and binds the E receptor, inhibited interferon\u2010\u03b3 production by human peripheral blood mononuclear leukocytes induced with the mitogens phytohemagglutinin, concanavalin A, Staphylococcal enterotoxin A and the monoclonal antibody OKT3. Metabolic activation (RNA and DNA synthesis) in human peripheral blood mononuclear leukocytes in response to mitogens was also sharply inhibited by 9.6. This inhibitory effect occurred early during the induction phase since 9.6 had much diminished inhibitory effects when added 15\u201024 h after induction; peak IFN\u2010\u03b3 production and DNA synthesis occurred 3\u20104 days post induction. An early event inhibited by 9.6 appeared to be interleukin 2 (IL2) receptor formation since: (a) the ability of mitogen\u2010stimulated peripheral blood mononuclear leukocytes to absorb IL2 was inhibited by 9.6, and (b) lines of T lymphocytes which already expressed IL2 receptors were largely resistant to the inhibitory effects of 9.6 on IFN\u2010\u03b3 production and DNA synthesis. The tumor promoters 12\u2010O\u2010tetradecanoyl phorbol\u201013\u2010acetate and teleocidin largely reversed the inhibition by 9.6 of IFN\u2010\u03b3 production and metabolic activation induced by mitogens. A model for the control of IFN\u2010\u03b3 induction involving four receptors, those for mitogens, tumor promoter, IL2 and erythrocyte, is proposed.<\/jats:p>","DOI":"10.1002\/eji.1830140807","type":"journal-article","created":{"date-parts":[[2007,2,28]],"date-time":"2007-02-28T21:24:29Z","timestamp":1172697869000},"page":"708-713","source":"Crossref","is-referenced-by-count":16,"title":["The E receptor regulates interferon\u2010gamma production: four\u2010receptor model for human lymphocyte activation"],"prefix":"10.1002","volume":"14","author":[{"given":"Miles","family":"Wilkinson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan","family":"Morris","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,16]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-7091-3432-0"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5699(83)90045-2"},{"key":"e_1_2_1_4_2","doi-asserted-by":"crossref","first-page":"2479","DOI":"10.4049\/jimmunol.129.6.2479","volume":"129","author":"Palacios R.","year":"1982","journal-title":"J. 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