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Within one week after infection, the production of IgG<jats:sub>2a<\/jats:sub> increased nearly 50\u2010fold whereas that of IgM, IgA, IgG<jats:sub>l<\/jats:sub> and IgG<jats:sub>3<\/jats:sub> remained virtually unchanged. IgG<jats:sub>2b<\/jats:sub> synthesis was also enhanced but to a lesser extent. Several observations suggested that this stimulation of IgG<jats:sub>2<\/jats:sub> production resulted from a polyclonal B cell activation: (a) the isoelectric focusing patterns of IgG<jats:sub>2a<\/jats:sub>, before and after LDV infection were exactly the same, (b) the frequency of clones with anti\u2010LDV activity in hybridoma collections derived from infected mice was extremely low (less than 4\/ 1000) and (c) the proliferative response elicited by LDV in unsensitized animals was comparable with that induced by lipopolysaccharide. The effect of LDV on immunoglobulin synthesis was drastically reduced in nude mice but was not affected by the X\u2010linked B lymphocyte defect of animals carrying the <jats:italic>xid<\/jats:italic> mutation.<\/jats:p>","DOI":"10.1002\/eji.1830150308","type":"journal-article","created":{"date-parts":[[2007,2,28]],"date-time":"2007-02-28T21:39:57Z","timestamp":1172698797000},"page":"250-255","source":"Crossref","is-referenced-by-count":49,"title":["Isotypically restricted activation of B lymphocytes by lactic dehydrogenase virus"],"prefix":"10.1002","volume":"15","author":[{"given":"Jean\u2010Paul","family":"Coutelier","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacques","family":"Van Snick","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,16]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/271066a0"},{"key":"e_1_2_1_3_2","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1128\/iai.34.1.140-143.1981","volume":"34","author":"Armstrong R. 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