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No such stimulation was observed with IgG<jats:sub>1<\/jats:sub>, IgM and IgA anti\u2010hapten antibodies. Depending on the antigen antibody combination, the amplification obtained after a single injection of IgG<jats:sub>2<\/jats:sub>\u2010complexed haptenated KLH ranged from 20\u2010 to 1000\u2010fold. By comparison, secondary responses were only marginally enhanced (\u2248 3\u2010fold) when IgG<jats:sub>2<\/jats:sub>\u2010complexed rather than free antigen was used to boost irradiated recipients previously reconstituted with primed spleen cells. The IgG<jats:sub>2<\/jats:sub>\u2010mediated enhancement was effective over a wide range of antigen\/antibody ratios, did not require the use of high affinity antibodies and occurred whatever the route of injection. The stimulation was specific for the complexed antigen and developed to the same extent whether complexes were formed <jats:italic>in vitro or in vivo<\/jats:italic>. A comparable stimulation of the anti\u2010carrier response was obtained with several other haptenated proteins but with formaldehyde\u2010treated diphtheria and tetanus toxoids inhibition rather than stimulation was observed.<\/jats:p>","DOI":"10.1002\/eji.1830150810","type":"journal-article","created":{"date-parts":[[2007,2,28]],"date-time":"2007-02-28T22:00:12Z","timestamp":1172700012000},"page":"793-798","source":"Crossref","is-referenced-by-count":79,"title":["Enhancement of IgG anti\u2010carrier responses by IgG<sub>2<\/sub> anti\u2010hapten antibodies in mice"],"prefix":"10.1002","volume":"15","author":[{"given":"Pierre G.","family":"Coulie","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacques","family":"van Snick","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,22]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-2776(08)60465-4"},{"key":"e_1_2_1_3_2","first-page":"195","volume":"19","author":"Fitch F. 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