{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T19:35:42Z","timestamp":1760297742376},"reference-count":38,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2005,11,22]],"date-time":"2005-11-22T00:00:00Z","timestamp":1132617600000},"content-version":"vor","delay-in-days":7630,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[1985,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Mice were immunized with a(1\u21926) dextran or its protein conjugate with monthly intervals, and their antibodies were quantitated with an isotype\u2010resolved radioimmunoassay. Plain dextran (molecular weight = 5\u201340 million) induced antibody concentrations varying from 20 to 80 \u03bcg\/ml (primary response). The resposse to a booster injection was weaker than the response to the first injection. More than 90% of anti\u2010dextran antibodies were IgM but IgG and IgA responses could be unequivocally demonstrated. IgG<jats:sub>1<\/jats:sub> and IgG<jats:sub>3<\/jats:sub> were the predominant subclasses of IgG. Dextran antibody responses to a conjugate of dextran (molecular weight \u2248 10 000) and chicken serum albumin (CSA) were stronger (80\u2013300 \u03bcg\/ml) than responses to plain dextran, and anti\u2010CSA responses to the conjugate were even stronger (up to 900 \u03bcg\/ml).<\/jats:p><jats:p>Three distinctly different isotype patterns were observed. A pattern IgM \u226b IgG<jats:sub>1<\/jats:sub> = IgG<jats:sub>3<\/jats:sub> &gt; IgG<jats:sub>2a<\/jats:sub> prevailed in responses to the plain dextran and in primary anti\u2010dextran responses to dextran\u2010CSA. Another pattern IgG<jats:sub>1<\/jats:sub> &gt; IgG<jats:sub>3<\/jats:sub> &gt; IgM &gt; IgG<jats:sub>2a<\/jats:sub> was observed in late anti\u2010dextran responses to dextran\u2010CSA. The third pattern IgG<jats:sub>1<\/jats:sub> \u226b IgG<jats:sub>2a<\/jats:sub> &gt; IgG<jats:sub>3<\/jats:sub> \u2248 IgM was characteristic of anti\u2010CSA antibodies. Little IgG<jats:sub>2b<\/jats:sub> or IgA antibodies were found. Different isotype patterns can best be explained on the basis of secondary factors such as T cell help.<\/jats:p>","DOI":"10.1002\/eji.1830150816","type":"journal-article","created":{"date-parts":[[2007,2,28]],"date-time":"2007-02-28T22:00:12Z","timestamp":1172700012000},"page":"827-833","source":"Crossref","is-referenced-by-count":22,"title":["Isotypes of antibodies induced by plain dextran or a dextran\u2010protein conjugate"],"prefix":"10.1002","volume":"15","author":[{"given":"Ilkka","family":"Sepp\u00e4l\u00e4","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jukka","family":"Pelkonen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olli","family":"M\u00e4kel\u00e4","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,22]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.4049\/jimmunol.103.6.1342","volume":"103","author":"Baker P. 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