{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:21:14Z","timestamp":1760188874159},"reference-count":30,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2005,11,22]],"date-time":"2005-11-22T00:00:00Z","timestamp":1132617600000},"content-version":"vor","delay-in-days":7265,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[1986,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A monoclonal antibody, CT4, which recognizes an antigenic determinant on the majority of guinea pig lymphocytes, was tested for its ability to interfere with adherence and homing capacity of lymphocytes. Incubation with F(ab\u2032)<jats:sub>2<\/jats:sub> fragments of the antibody blocks the <jats:italic>in vitro<\/jats:italic> binding to high endothelial venules (HEV) of both peripheral lymph nodes and Peyer's patches. When tested <jats:italic>in vivo<\/jats:italic> using a short\u2010term homing assay with radiolabeled cells also a reduction of migration into the spleen was observed. Fluorescence\u2010activated cell sorter analysis of lymph node cells showed a separation into duller and brightly positive cells whereas in the thymus the bright population is absent. Thymus cells adhere less effectively to HEV and this binding can only marginally be blocked by CT4 incubation. The results suggest a role of CT4 in adhesion processes.<\/jats:p>","DOI":"10.1002\/eji.1830161208","type":"journal-article","created":{"date-parts":[[2007,2,28]],"date-time":"2007-02-28T22:41:48Z","timestamp":1172702508000},"page":"1515-1519","source":"Crossref","is-referenced-by-count":20,"title":["A surface molecule on guinea pig lymphocytes involved in adhesion and homing"],"prefix":"10.1002","volume":"16","author":[{"given":"Georg","family":"Kraal","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agaath","family":"Twisk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ben","family":"Tan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rik","family":"Scheper","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,22]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.1964.0001"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.1964.0002"},{"key":"e_1_2_1_4_2","first-page":"1","volume":"727","author":"Goldschneider I.","year":"1968","journal-title":"J. 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