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USA<\/jats:italic> 1986. <jats:italic>83:<\/jats:italic> 2061). In this report we tested recombinant IL4 in various T cell assays. It was found that IL4 activated the murine T cell line CTLL to increased DNA synthesis but not to growth. It also activated normal concanavalin A (Con A)\u2010stimulated T cells both to increased DNA synthesis and to growth. These T cell growth factor\u2010like activities were not inhibitable by anti\u2010IL2 receptor antibodies. Evidence is given that both Lyt\u20102<jats:sup>+<\/jats:sup> and L3T4<jats:sup>+<\/jats:sup> T cells responded to IL4. Finally, IL4 acted synergistically with phytohemagglutinin or Con A on normal T lymphocytes as well as on thymocytes. 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