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Analysis of transgenic mice bearing single\u2010copy integrations of the injected DNA indicates that provision of the enhancer downstream of the test gene (beyond the polyadenylation site) is sufficient to direct lymphoid\u2010specific expression. The tissue specificity is considerable as judged by the fact that transgene expression is at least one thousandfold higher in spleen than in liver. Within the lymphoid family, expression of the transgene is much higher in surface IgM<jats:sup>+<\/jats:sup> spleen cells than in thymocytes high in Thy\u20101 expression, suggesting that the enhancer preferentially directs expression to cells of the B lineage.<\/jats:p>","DOI":"10.1002\/eji.1830170405","type":"journal-article","created":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T00:47:54Z","timestamp":1172710074000},"page":"465-469","source":"Crossref","is-referenced-by-count":25,"title":["Provision of the immunoglobulin heavy chain enhancer downstream of a test gene is sufficient to confer lymphoid\u2010specific expression in transgenic mice"],"prefix":"10.1002","volume":"17","author":[{"given":"Wolf","family":"Reik","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gareth","family":"Williams","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheila","family":"Barton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mike","family":"Norris","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Neuberger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. 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