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Distinct restriction site patterns were found for the CH genes and for V<jats:sub>H<\/jats:sub> families PC7183, Q52 and X24. V<jats:sub>H<\/jats:sub> families V31 and J558 showed identical patterns. Mixed patterns of identical and distinct bands were detected in V<jats:sub>H<\/jats:sub> families S107, J606, V3660 and VGAM3.8. This indicates that a recombination took place involving the Igh loci of a <jats:italic>M. m. molossinus<\/jats:italic> and a progenitor of the C57BL\/6 strain. The breakpoint of recombination maps to the chromosomal region carrying V<jats:sub>H<\/jats:sub> families S107, J606, VGAM3.8 and V3660. V<jats:sup>H<\/jats:sup> families PC7183, Q52 and X24 map 3\u2032 to the recombination breakpoint and proximal to the D<jats:sub>H<\/jats:sub>\u2010J<jats:sub>H<\/jats:sub>\u2010C<jats:sub>H<\/jats:sub> region, whereas V<jats:sub>H<\/jats:sub> families V31 and J558 accordingly map 5\u2032 to the recombination breakpoint and distal to D<jats:sub>H<\/jats:sub>\u2010J<jats:sub>H<\/jats:sub>\u2010C<jats:sub>H<\/jats:sub>. This order of V<jats:sub>H<\/jats:sub> families was confirmed by deletion mapping utilizing hybridomas which are haploid either for the Igh<jats:sup>b<\/jats:sup> or for the Igh<jats:sup>a<\/jats:sup> locus. The mapping data indicate that the V<jats:sup>H<\/jats:sup> families of the mouse are organized in overlapping clusters. This notion is confirmed by demonstration of the physical linkage of V<jats:sub>H<\/jats:sub> genes from families V31 and J558 in the Igh<jats:sup>a<\/jats:sup> locus.<\/jats:p>","DOI":"10.1002\/eji.1830170920","type":"journal-article","created":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T00:51:04Z","timestamp":1172710264000},"page":"1351-1357","source":"Crossref","is-referenced-by-count":35,"title":["Immunoglobulin V<sub>H<\/sub> region genes of the mouse are organized in overlapping clusters"],"prefix":"10.1002","volume":"17","author":[{"given":"Thomas","family":"Blankenstein","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrich","family":"Krawinkel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,17]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830141012"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5699(84)90034-3"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1985.tb04015.x"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.75.9.4494"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01892405"},{"key":"e_1_2_1_7_2","first-page":"89","volume-title":"Handbook of Experimental Immunology","author":"Riblet R.","year":"1986"},{"key":"e_1_2_1_8_2","first-page":"245","volume":"1","author":"Kemp D. 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