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In this report the relationship is explored between the antigen\u2010specific unresponsiveness and activation pathways triggered via the T cell receptor and Thy\u20101: the latter pathway is dependent on the former. A mitogenic anti\u2010Thy\u20101 antibody (KT16) made the T cell clone unresponsive to specific antigen and to an anti\u2010T cell receptor antibody coupled to Sepharose. The unresponsiveness lasted for at least 7 days. However, cells made unresponsive to specific antigen in these ways (the T cell receptor and Thy\u20101) could be activated by both interleukin 2 and KT16. KT16 down\u2010modulated the T cell receptor immediately after the pretreatment, but not on day 7 after the pretreatment. These facts indicate that the state of the unresponsiveness was caused by blocking transduc\u2010tion of an activation signal triggered by the T cell receptor to an activation pathway shared by the T cell receptor and Thy\u20101.<\/jats:p>","DOI":"10.1002\/eji.1830180127","type":"journal-article","created":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T00:50:13Z","timestamp":1172710213000},"page":"179-182","source":"Crossref","is-referenced-by-count":19,"title":["Down\u2010regulation of the T cell receptor by a mitogenic anti\u2010Thy\u20101 antibody"],"prefix":"10.1002","volume":"18","author":[{"given":"Kyuhei","family":"Tomonari","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,22]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0008-8749(85)90347-8"},{"key":"e_1_2_1_3_2","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.4049\/jimmunol.131.4.1641","volume":"131","author":"Tomonari K.","year":"1983","journal-title":"J. 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